Kleinrok Z, Chmielewska B, Czuczwar J S, Rajtar G, Sawiniec Z, Jarzabek G
Arch Immunol Ther Exp (Warsz). 1986;34(3):293-304.
Some pharmacological properties of commercial racemic ifosfamide (Holoxan) and its D- and L-enantiomers were compared in experiments on mice and rats. Although values of acute toxicity and some results of subchronic treatment revealed better parameters of L-form in comparison to racemic mixture, distinct hepatotoxic effects and thrombocytopenia noted in the course of prolonged treatment seem to be the important factors limiting therapeutic usefulness of levorotatory form.
在小鼠和大鼠实验中比较了市售消旋异环磷酰胺（和乐生）及其D-和L-对映体的一些药理学特性。尽管急性毒性值和亚慢性治疗的一些结果显示L-型与消旋混合物相比具有更好的参数，但在长期治疗过程中观察到的明显肝毒性作用和血小板减少似乎是限制左旋体治疗效用的重要因素。
