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The PrEP Cascade in a National Cohort of Adolescent Men Who Have Sex With Men.青少年男男性行为者全国队列中的 PrEP 级联。
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艾滋病病毒预防指标:从避孕措施中吸取的经验教训。

HIV prevention metrics: lessons to be learned from contraception.

机构信息

University of Chicago, Chicago, Illinois, USA.

University of Washington, Seattle, Washington, USA.

出版信息

J Int AIDS Soc. 2022 Aug;25(8):e25958. doi: 10.1002/jia2.25958.

DOI:10.1002/jia2.25958
PMID:35929343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9353407/
Abstract

INTRODUCTION

As the range of effective HIV prevention options, including multiple biomedical tools, increases, there are many challenges to measuring HIV prevention efforts. In part, there is the challenge of varying prevention needs, between individuals as well as within individuals over time. The field of contraception faces many similar challenges, such as the range of prevention methods and changing contraceptive needs, and has developed many metrics for assessing contraceptive use at the program level, using frameworks that move beyond the HIV prevention cascade. We explore these similarities and differences between these two prevention fields and then discuss how each of these contraceptive metrics could be adapted to assessing HIV prevention.

DISCUSSION

We examined measures of initiation, coverage and persistence. Among measures of initiation, HIV Prevention-Post Testing would be a useful corollary to Contraceptive Use-Post Partum for a subset of the population. As a measure of coverage, both Net Prevention Coverage and HIV Protection Index (modelled off the Contraception Protection Index) may be useful. Finally, as a measure of persistence, Person-Years of HIV Protection could be adapted from Couple-Years Protection. As in contraception, most programs will not reach 100% on HIV prevention metrics but these metrics are highly useful for making comparisons.

CONCLUSIONS

While we may not be able to perfectly capture the true population of who would benefit from HIV prevention, by building off the work of the contraceptive field to use and refine these metrics, we can assess and compare HIV prevention over time and across programs. Furthermore, these metrics can help us reach global targets, such as the 2025 UNAIDS Goals, and reduce HIV incidence.

摘要

简介

随着有效的 HIV 预防选择(包括多种生物医学工具)范围的扩大,衡量 HIV 预防工作面临许多挑战。部分原因是个体之间以及个体随时间变化的预防需求存在差异。避孕领域也面临着许多类似的挑战,例如预防方法的多样性和不断变化的避孕需求,并已开发出许多衡量计划生育方案中避孕措施使用情况的指标,这些指标采用了超越 HIV 预防环节的框架。我们探讨了这两个预防领域之间的相似性和差异,然后讨论了如何调整这些避孕指标来评估 HIV 预防。

讨论

我们研究了起始、覆盖和持续的措施。在起始措施中,对于一部分人群,HIV 预防 - 检测后可以作为避孕使用 - 产后的有用补充。作为覆盖措施,净预防覆盖率和 HIV 保护指数(模仿避孕保护指数)都可能有用。最后,作为持续措施,个人 HIV 保护年数可以从夫妻保护年数中进行调整。与避孕一样,大多数方案无法达到 HIV 预防指标的 100%,但这些指标对于进行比较非常有用。

结论

虽然我们可能无法完全捕捉到真正受益于 HIV 预防的人群,但可以借鉴避孕领域的工作来使用和完善这些指标,从而评估和比较随时间和方案变化的 HIV 预防情况。此外,这些指标有助于我们实现全球目标,如 2025 年联合国艾滋病规划署目标,并降低 HIV 发病率。