Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
FEBS J. 2022 Nov;289(21):6460-6462. doi: 10.1111/febs.16577. Epub 2022 Aug 5.
Skeletal muscle is a structurally and functionally remarkable tissue composed of multinucleated post-mitotic muscle fibres. These fibres are filled with an exquisite, near crystalline array of assembled contractile proteins, capable of coupling ATP utilization to mechanical muscle contraction. Fully differentiated muscle has an incredible ability to protect and repair itself from significant muscle injuries. In fact, through activation of a resident population of stem cells known as satellite cells, muscle fibres can be completely regenerated, and normal function can be restored in a matter of a few weeks after a major myocellular necrotic injury. The loss of key mechanisms to protect muscle from injuries or loss of the capacity to repair muscle after injury is thought to underlie several forms of muscular dystrophy and also the age-related decline of muscle function. In this Subject Collection, The FEBS Journal highlights articles that review or investigate key mechanisms of muscle repair and regeneration in response to injuries, and the contributions of these pathways to health and disease of skeletal muscle.
骨骼肌是一种结构和功能都非常特殊的组织，由多核的有丝后肌肉纤维组成。这些纤维充满了精致的、近乎结晶状的组装收缩蛋白阵列，能够将 ATP 的利用与机械肌肉收缩相偶联。完全分化的肌肉具有令人难以置信的自我保护和修复能力，可以防止肌肉受到严重损伤。事实上，通过激活被称为卫星细胞的常驻干细胞群，肌肉纤维可以被完全再生，并且在经历主要肌细胞坏死损伤后的数周内，肌肉功能可以恢复正常。人们认为，缺乏保护肌肉免受损伤的关键机制，或者在损伤后修复肌肉的能力丧失，是几种形式的肌肉萎缩症以及与年龄相关的肌肉功能下降的基础。在本主题集中，《FEBS 杂志》重点介绍了综述或研究肌肉修复和再生的关键机制以应对损伤，以及这些途径对骨骼肌健康和疾病的贡献的文章。
