Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Diagn Cytopathol. 2022 Dec;50(12):E357-E360. doi: 10.1002/dc.25028. Epub 2022 Aug 5.
Anaplastic thyroid carcinoma is an infrequent, but aggressive fatal subtype of thyroid cancer. The osteoclastic variant of anaplastic carcinoma is a rare subtype of anaplastic carcinoma with rare cases reported in the literature. Molecular targeted therapies have emerged for the anaplastic carcinoma, necessitating accurate pathologic diagnosis with additional ancillary testing for directing clinical management. We present here the cytological diagnosis of an anaplastic thyroid carcinoma-osteoclastic variant on fine-needle aspiration (FNA), with emphasis on the novelty of utilizing the least invasive procedure (aspiration cytology) for rendering pathological diagnosis as well as identifying potential prognostic markers for targeted immunotherapy.
间变性甲状腺癌是一种罕见但具有侵袭性的致命性甲状腺癌亚型。破骨细胞型间变性癌是一种罕见的间变性癌亚型，文献中报道的病例很少。针对间变性癌出现了分子靶向治疗，因此需要进行准确的病理诊断，并通过额外的辅助检测来指导临床管理。本文介绍了一例细针抽吸活检（FNA）诊断的间变性甲状腺癌-破骨细胞型，重点介绍了利用最微创的程序（抽吸细胞学）进行病理诊断以及识别潜在的靶向免疫治疗预后标志物的新颖性。
