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一例罕见的间变性甲状腺癌病例报告:同一甲状腺的不同叶分别出现破骨细胞样变异型和鳞状细胞癌两种不同模式,类似碰撞瘤。

A unique case of anaplastic thyroid carcinoma comprising of two distinct patterns osteoclastic variant and squamous cell carcinoma in separate lobe imitating collision tumor: A case report.

作者信息

Gupta Rakesh Kumar, John Aishwarya, Ravina Mudalsha, Arora Ripu Daman

机构信息

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, India.

Department of Nuclear Medicine, All India Institute of Medical Sciences, Raipur, India.

出版信息

Diagn Cytopathol. 2023 Mar;51(3):E89-E93. doi: 10.1002/dc.25085. Epub 2022 Dec 1.

DOI:10.1002/dc.25085
PMID:36458378
Abstract

Anaplastic thyroid carcinoma with two distinct morphologies in two lobes with no intermixing is very rare and not reported earlier. Furthermore, osteoclastic variant of anaplastic thyroid carcinoma as well as primary squamous cell carcinoma without any differentiated components are also very rare with only few reported cases describing their cytological features. Herein, we are reporting a unique and first case of anaplastic thyroid carcinoma comprising of two distinct patterns osteoclastic variant and squamous cell carcinoma in different lobes in a 55-years-old lady with review of literature.

摘要

在两个叶中具有两种不同形态且互不混合的间变性甲状腺癌非常罕见,此前未见报道。此外,间变性甲状腺癌的破骨细胞样变体以及无任何分化成分的原发性鳞状细胞癌也非常罕见,仅有少数病例报道描述了它们的细胞学特征。在此,我们报告一例独特的首例间变性甲状腺癌病例,该病例发生在一位55岁女性患者的不同叶中,包含破骨细胞样变体和鳞状细胞癌两种不同模式,并对相关文献进行了回顾。

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A unique case of anaplastic thyroid carcinoma comprising of two distinct patterns osteoclastic variant and squamous cell carcinoma in separate lobe imitating collision tumor: A case report.一例罕见的间变性甲状腺癌病例报告:同一甲状腺的不同叶分别出现破骨细胞样变异型和鳞状细胞癌两种不同模式,类似碰撞瘤。
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引用本文的文献

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Primary Squamous Cell Carcinoma of the Thyroid Has a Molecular Genetic Profile Distinct From That of Anaplastic Thyroid Carcinoma: A Whole Exome Sequencing and Gene Expression Profiling Study.甲状腺原发性鳞状细胞癌具有与间变性甲状腺癌不同的分子遗传特征:一项全外显子组测序和基因表达谱研究
Am J Surg Pathol. 2024 Aug 1;48(8):1024-1031. doi: 10.1097/PAS.0000000000002251. Epub 2024 May 22.