Sachdeva Rahul, Kalimullina Tamila, Pawar Kiran, Krassioukov Andrei
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.
Department of Medicine, University of British Columbia, Vancouver, Canada.
J Neurotrauma. 2022 Dec;39(23-24):1764-1768. doi: 10.1089/neu.2022.0274. Epub 2022 Oct 3.
Spinal cord injury (SCI) results in devastating cardiovascular dysfunction. Noxious stimuli from the rectum during bowel routine often trigger life-threatening blood pressure surges, termed autonomic dysreflexia (AD). Rectal application of anesthetic lidocaine jelly has been recommended during bowel care to reduce AD severity by mitigating sensory input. However, clinical studies have reported contradicting evidence. We performed a pre-clinical study on the efficacy of rectal lidocaine in a standardized rodent T3 transection model. We found that 2% and 10% lidocaine significantly reduced AD severity by 32% and 50%, respectively, compared with control ( < 0.0001). Our pre-clinical experiments support the current recommendation of rectal lidocaine application during bowel care.
脊髓损伤（SCI）会导致严重的心血管功能障碍。肠道护理期间来自直肠的有害刺激常常引发危及生命的血压飙升，即自主神经反射异常（AD）。在肠道护理期间，建议直肠应用麻醉利多卡因凝胶，以通过减轻感觉输入来降低AD的严重程度。然而，临床研究报告了相互矛盾的证据。我们在标准化的啮齿动物T3横断模型中对直肠利多卡因的疗效进行了临床前研究。我们发现，与对照组相比，2%和10%的利多卡因分别使AD严重程度显著降低了32%和50%（< 0.0001）。我们的临床前实验支持目前在肠道护理期间直肠应用利多卡因的建议。
