Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Andrology. 2022 Nov;10(8):1548-1555. doi: 10.1111/andr.13259. Epub 2022 Aug 16.
Low-grade systemic inflammation and malnutrition are frequently observed in patients on dialysis and contribute to the development of endothelial dysfunction; however, the role of these conditions in erectile dysfunction (ED) severity remains to be elucidated.
To investigate the relationships of low-grade systemic inflammation and nutritional status with ED severity in men on dialysis.
The present study included 71 men on dialysis. The sexual health inventory for men (SHIM) was used to assess ED. Men were classified as the mild/moderate (SHIM score ≥ 8) and severe ED (SHIM score ≤ 7) groups. C-reactive protein/albumin ratio (CAR) and Geriatric Nutritional Risk Index (GNRI) were used to evaluate low-grade systemic inflammation and nutritional status, respectively. We performed multivariate analysis to assess the relationships of CAR and GNRI with severe ED.
The median age of the included men was 64 years old. All men had any degree of ED with 65% having severe ED. In the univariate analyses, a significant association was observed between elevated CAR (≥0.09) and severe ED (odds ratio [OR]: 4.038, p = 0.025), whereas no significant association was observed between lower GNRI (<92) and severe ED (OR: 2.357, p = 0.109). In the multivariate analysis, an association between elevated CAR and severe ED was still significant (OR: 5.985, p = 0.010).
Low-grade systemic inflammation was significantly associated with ED severity, whereas lower GNRI was not. These results may be helpful for further research to identify the optimal treatment for men suffering from severe ED.
低水平系统性炎症和营养不良在透析患者中经常观察到，这有助于内皮功能障碍的发展；然而，这些情况在勃起功能障碍（ED）严重程度中的作用仍有待阐明。
研究低水平系统性炎症和营养状况与透析男性 ED 严重程度的关系。
本研究纳入了 71 名透析男性。使用男性性健康问卷（SHIM）评估 ED。将男性分为轻度/中度（SHIM 评分≥8）和严重 ED（SHIM 评分≤7）组。使用 C 反应蛋白/白蛋白比值（CAR）和老年营养风险指数（GNRI）分别评估低水平系统性炎症和营养状况。我们进行了多变量分析，以评估 CAR 和 GNRI 与严重 ED 的关系。
纳入男性的中位年龄为 64 岁。所有男性均有不同程度的 ED，其中 65%患有严重 ED。在单变量分析中，CAR 升高（≥0.09）与严重 ED 显著相关（优势比[OR]：4.038，p=0.025），而 GNRI 降低（<92）与严重 ED 无显著相关性（OR：2.357，p=0.109）。在多变量分析中，CAR 升高与严重 ED 之间仍存在显著相关性（OR：5.985，p=0.010）。
低水平系统性炎症与 ED 严重程度显著相关，而 GNRI 降低则无相关性。这些结果可能有助于进一步研究，以确定治疗严重 ED 男性的最佳治疗方法。
