The Department of Urology, Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Graduate School, Guangxi Medical University, Nanning, China.
Immun Inflamm Dis. 2024 Aug;12(8):e1363. doi: 10.1002/iid3.1363.
Erectile dysfunction (ED) is associated with inflammation. The systematic immune-inflammation index (SII), as a new inflammation marker, was applied to predict the risk of diseases. However, no research explores the relationship between SII and ED. Hence, the purpose of this study was to investigate the association between SII and ED.
Related data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Based on self-report, all participants were classified into ED and non-ED group. Weighted multivariate regression analysis the relationship between categorical SII and ED in unadjusted and adjusted models. Restricted cubic spline (RCS) was used to examine the association of continuous SII and ED risk. Furthermore, the association between categorical SII and the risk of ED was evaluated among subgroups of age, body mass index, hypertension, diabetes and cardiovascular disease. Finally, weighted multivariate regression analysis and RCS were performed to assessed the connection between SII and the risk of severe ED.
Initially, data on 21,161 participants were obtained. After implementing the inclusion and exclusion criteria, 3436 participants were included in analyses. Weighted multivariate regression analysis demonstrated that Q4 group SII was associated with an increased risk of ED (OR = 1.03, 95% confidence intervals: 1.00-1.05, p = .03). RCS showed SII was nonlinearly associated with the risk of ED, and the inflection point of SII was at 485.530. In addition, subgroup analyses demonstrated that participants in the SII > 485.530 group had a higher ED risk than SII ≤ 485.530 group among subgroups of age ≥50, hypertension, and non-diabetes. Weighted multivariate regression analysis and RCS found no relationship of SII and the risk of severe ED.
In US adults, SII > 485.530 was correlated with an increased risk of ED. While, no significant association between SII and severe ED risk. Additional studies are required to support our results.
勃起功能障碍（ED）与炎症有关。系统性免疫炎症指数（SII）作为一种新的炎症标志物，已被用于预测疾病风险。然而，目前尚无研究探讨 SII 与 ED 之间的关系。因此，本研究旨在探讨 SII 与 ED 之间的关系。
本研究相关数据来源于 2001-2004 年全国健康和营养调查（NHANES）。根据自我报告，所有参与者被分为 ED 和非 ED 组。在未调整和调整模型中，使用加权多变量回归分析 SII 与 ED 之间的关系。限制性三次样条（RCS）用于评估连续 SII 与 ED 风险之间的关系。此外，还评估了 SII 与年龄、体重指数、高血压、糖尿病和心血管疾病亚组中 ED 风险的关系。最后，进行加权多变量回归分析和 RCS 以评估 SII 与严重 ED 风险之间的关系。
最初，共获得 21161 名参与者的数据。实施纳入和排除标准后，有 3436 名参与者纳入分析。加权多变量回归分析表明，Q4 组 SII 与 ED 风险增加相关（OR=1.03，95%置信区间：1.00-1.05，p=0.03）。RCS 显示 SII 与 ED 风险呈非线性相关，SII 的拐点为 485.530。此外，亚组分析表明，SII＞485.530 组的参与者比 SII≤485.530 组的 ED 风险更高，且年龄≥50 岁、高血压和非糖尿病的亚组中尤其如此。加权多变量回归分析和 RCS 发现 SII 与严重 ED 风险无关。
在美国成年人中，SII＞485.530 与 ED 风险增加相关。然而，SII 与严重 ED 风险之间无显著关联。需要进一步的研究来支持我们的结果。
