Onuk Özkan, Arslan Burak, Gezmis Tugrul Cem, Çetin Bugra, Göv Taha, Yazıcı Gökhan, Gürkan Okan, Ozdemir Enver
Department of Urology, Yeni Yüzyıl University, Istanbul, Turkey.
Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research Hospital, Karayolları Str. No:621 Gaziosmanpaşa, Istanbul, Turkey.
Int Urol Nephrol. 2018 Sep;50(9):1577-1582. doi: 10.1007/s11255-018-1946-2. Epub 2018 Jul 27.
The aim of our study was to assess the correlation between serum endocan level and erectile dysfunction (ED).
A total of 92 patients were reviewed in this study after institutional review board approval. The patients' characteristics were recorded, including age, body mass index, blood pressure, smoking history, serum creatinine, glucose, lipid profile, total testosterone, and Beck Depression Inventory scores. ED was evaluated with the Sexual Health Inventory for Men (SHIM) questionnaire and classified as severe, moderate, or mild. Scores of > 18 indicate normal erectile function and were recruited for the control group.
Sixty-three patients with a median age of 56 years in the ED group and 29 patients with a median age of 55 years in the control group were compared. ED was classified as severe in 20, moderate in 25, and mild in 18 patients. A significant difference was determined between the severe ED group and the control group for serum endocan levels (p < 0.001). A significant negative correlation between the SHIM score and endocan levels (rho - 0.65; p < 0.01), age and SHIM score (rho - 0.32; p = 0.04), BMI and SHIM score (rho - 0.25; p = 0.03), and BMI and total testosterone (rho - 0.16; p = 0.04) was determined upon Spearman's correlation analysis. A positive correlation was also determined between total testosterone and SHIM score (rho 0.50; p = 0.04). Patients' age (p = 0.037) and serum endocan level (p = 0.029) were determined as significant in the multivariate analysis.
This study demonstrated the presence of an association between plasma endocan levels and ED. Endocan may be used as a new diagnostic marker for the severity of ED.
本研究旨在评估血清内脂素水平与勃起功能障碍（ED）之间的相关性。
本研究经机构审查委员会批准，共纳入92例患者。记录患者的特征，包括年龄、体重指数、血压、吸烟史、血清肌酐、血糖、血脂谱、总睾酮以及贝克抑郁量表评分。采用男性性健康量表（SHIM）问卷评估ED，并将其分为重度、中度或轻度。得分>18表明勃起功能正常，这些患者被纳入对照组。
比较了ED组63例中位年龄为56岁的患者和对照组29例中位年龄为55岁的患者。ED患者中，重度20例，中度25例，轻度18例。重度ED组与对照组的血清内脂素水平存在显著差异（p<0.001）。经Spearman相关性分析，SHIM评分与内脂素水平（rho - 0.65；p<0.01）、年龄与SHIM评分（rho - 0.32；p = 0.04）、BMI与SHIM评分（rho - 0.25；p = 0.03）以及BMI与总睾酮（rho - 0.16；p = 0.04）之间存在显著负相关。总睾酮与SHIM评分之间也存在正相关（rho 0.50；p = 0.04）。多因素分析确定患者年龄（p = 0.037）和血清内脂素水平（p = 0.029）具有显著性。
本研究表明血浆内脂素水平与ED之间存在关联。内脂素可作为ED严重程度的一种新的诊断标志物。
