Yang H Y, Liao J F, Shum A Y, Chen C F
Artery. 1987;14(3):154-64.
In vitro effects of ethanol (0.1-2.0%,v/v) on canine vasculer smooth muscle were studied. Ethanol dose-dependently produced inhibition in both the amplitude and frequency of the spontaneous rhythmic activity of the canine hepatic portal vein, and at concentration of 1.0 +/- 0.2% completely abolished the spontaneous activity. Ethanol evoked dose-dependent constriction, rather than dilatation, in all vascular smooth muscles tested, including femoral, renal, common carotid, and pulmonary arteries, and external jugular, splenic, pulmonary, femoral, renal, and hepatic portal veins. The vasoconstriction effect of ethanol was much stronger on arteries than on the corresponding veins. Based on the contractile tension developed by ethanol, the femoral artery or the external jugular vein appeared to be most sensitive to ethanol among the arteries or veins preparations tested. The present results suggested that ethanol, depending on concentration, may either enhance or decrease excitability of vascular smooth muscles. There were also regional differences of effects of ethanol on canine blood vessels.
研究了乙醇（0.1 - 2.0%，v/v）对犬类血管平滑肌的体外作用。乙醇剂量依赖性地抑制犬肝门静脉自发性节律活动的幅度和频率，在浓度为1.0±0.2%时完全消除自发性活动。在所有测试的血管平滑肌中，包括股动脉、肾动脉、颈总动脉和肺动脉，以及颈外静脉、脾静脉、肺静脉、股静脉、肾静脉和肝门静脉，乙醇引起剂量依赖性收缩而非扩张。乙醇对动脉的血管收缩作用比对相应静脉的作用要强得多。根据乙醇产生的收缩张力，在测试的动脉或静脉制剂中，股动脉或颈外静脉似乎对乙醇最敏感。目前的结果表明，乙醇根据浓度不同，可能增强或降低血管平滑肌的兴奋性。乙醇对犬类血管的作用也存在区域差异。
