Masuda E, Kawano S, Nagano K, Tsuji S, Ishigami Y, Hayashi N, Tsujii M, Sasayama Y, Michida T, Fusamoto H
First Department of Medicine, Osaka University Medical School, Japan.
Gastroenterol Jpn. 1991 Jul;26 Suppl 3:81-2. doi: 10.1007/BF02779270.
The effects of ethanol on gastric vasculature in isolated vascularly perfused rabbit stomach was investigated. The isolated stomach was perfused with Krebs-Henseleit solution containing 3% dextran bubbled with 95% O2 and 5% CO2 at a rate of 12 ml/min. After mixture and perfusion of 10 mM to 400 mM of ethanol, perfusion pressure and endothelin-1 concentration in effluent from gastric vasculature were measured. Perfusion pressure and endothelin-1 concentration in effluent increased in a dose-dependent manner with increasing ethanol concentrations. In conclusion, the data suggest that ethanol may stimulate the release of endothelin from gastric vasculature and may cause gastric ischemia due to vasoconstriction resulting in acute gastric mucosal injury.
研究了乙醇对离体血管灌注兔胃胃血管系统的影响。将离体胃用含有3%右旋糖酐的Krebs-Henseleit溶液灌注，该溶液以95% O₂和5% CO₂鼓泡，流速为12 ml/min。在混合并灌注10 mM至400 mM乙醇后，测量胃血管流出液中的灌注压力和内皮素-1浓度。随着乙醇浓度的增加，流出液中的灌注压力和内皮素-1浓度呈剂量依赖性增加。总之，数据表明乙醇可能刺激胃血管系统释放内皮素，并可能由于血管收缩导致急性胃黏膜损伤而引起胃缺血。
