Zerbino D D, Lutsik A D, Kotyk A E, Gavriliuk E M, Dmitruk I M
Arkh Patol. 1987;49(3):20-5.
By means of lectin-peroxidase technique histotopography of receptor sites for Ricinus communis agglutinin (RCA), peanut agglutinin (PA), soybean agglutinin (SA), Sophora japonica lectin (SJL), wheat germ agglutinin (WGA), Laburnum anagyroides lectin (LAL), Lotus tetragonolobus lectin (LTL) and concanavalin A (con A) in normal aortic tissue sections as well as in dissecting aortic aneurysms (Gsell-Erdheim syndrome) has been investigated. It was demonstrated that fucose-specific LAL and LTL possess high selectivity of binding to aortic endotheliocytes, SA to neurocytes of autonomic nervous nodes. Gsell-Erdheim syndrome is accompanied by appearance of SA-binding sites around smooth myocytes with formation of specific SA-positive multivesicular shapes in aortic media. Possible role of the observed phenomena in pathogenesis of dissecting aortic aneurysm is discussed.
采用凝集素-过氧化物酶技术，对正常主动脉组织切片以及夹层主动脉瘤（格塞尔-埃德海姆综合征）中蓖麻凝集素（RCA）、花生凝集素（PA）、大豆凝集素（SA）、槐凝集素（SJL）、麦胚凝集素（WGA）、金链花凝集素（LAL）、百脉根凝集素（LTL）和伴刀豆球蛋白A（Con A）的受体位点进行了组织定位研究。结果表明，岩藻糖特异性的LAL和LTL对主动脉内皮细胞具有高度的结合选择性，SA对自主神经节的神经细胞具有高度的结合选择性。格塞尔-埃德海姆综合征伴有平滑肌细胞周围SA结合位点的出现，并在主动脉中层形成特定的SA阳性多囊泡形态。讨论了所观察到的现象在夹层主动脉瘤发病机制中的可能作用。
