Aruin L I, Loginov A S, Shatalova O L
Arkh Patol. 1987;49(3):31-7.
The material from 113 point liver biopsies was studied. In 11 biopsy samples hepatic cirrhosis of viral origin was diagnosed, in 15 there was an alcoholic cirrhosis of the liver, and in 23--primary biliary cirrhosis. The comparative group included 8 patients with CPG, 13 with CAG, 32 with alcohol induced fatty dystrophy and 12 with non-alcoholic fatty dystrophy. Twenty six biopsy samples in which there were no inflammatory changes, the hepatic structure was unaltered, were used as controls. Stellate reticuloendotheliocytes were identified by means of acid-alpha-naphthyl-acetate esterase test. Quantitative assessment of stellate reticuloendotheliocytes (SR) was made stereometrically. In cases of primary biliary cirrhosis (PBC), active viral and alcoholic cirrhosis significant SR activation was found (due to hepatic parenchyma necroses) to maintain homeostasis. The biggest SR activation was revealed in PBC which is connected with the involvement of the immune mechanisms in this disease.
对113份肝穿刺活检材料进行了研究。在11份活检样本中诊断出病毒性肝硬化，15份为酒精性肝硬化，23份为原发性胆汁性肝硬化。对照组包括8例慢性持续性肝炎患者、13例慢性活动性肝炎患者、32例酒精性脂肪营养不良患者和12例非酒精性脂肪营养不良患者。26份无炎症改变、肝脏结构未改变的活检样本用作对照。通过酸性α-萘乙酸酯酶试验鉴定星状网状内皮细胞。采用立体测量法对星状网状内皮细胞（SR）进行定量评估。在原发性胆汁性肝硬化（PBC）、活动性病毒性和酒精性肝硬化病例中，发现SR显著激活（由于肝实质坏死）以维持内环境稳定。PBC中SR激活最为明显，这与该疾病中免疫机制的参与有关。
