邻里关系很重要：APOE4 小胶质细胞中脂质代谢的改变会给神经元带来问题。
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons.
机构信息
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Department of Neurology, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
出版信息
Cell Stem Cell. 2022 Aug 4;29(8):1159-1160. doi: 10.1016/j.stem.2022.07.001.
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer's disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.
在本期《Cell Stem Cell》杂志上，Victor 等人揭示了携带阿尔茨海默病风险等位基因 APOE4 的人类小胶质细胞存在脂质代谢和细胞激活异常。这会抑制神经元网络活动，强调了这些驻留于大脑的免疫细胞的重要性，并突出了一种新的治疗干预途径。
Zotero 插件