免疫球蛋白 M 对肺炎球菌多糖疫苗的反应足以提供免疫力。
The Immunoglobulin M Response to Pneumococcal Polysaccharide Vaccine Is Sufficient for Conferring Immunity.
机构信息
Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Division of Allergy and Clinical Immunology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
出版信息
J Infect Dis. 2022 Nov 11;226(10):1852-1856. doi: 10.1093/infdis/jiac339.
In mice, pneumococcal polysaccharide (PPS) vaccines generate antigen-specific immunoglobulin M (IgM) and immunoglobulins G1, G2, and G3. Antibody and complement-dependent opsonophagocytosis correlates with the protection induced by PPS vaccines in vivo. Since IgM is a very efficient immunoglobulin isotype in activating the complement system, we evaluated whether anti-PPS IgM alone is sufficient to confer protective immunity to Streptococcus pneumoniae. We found that immunization of wild-type and activation-induced cytidine deaminase-deficient mice capable of producing only IgM with Pneumovax 23 generated comparable anti-PPS IgM and resistance to lethal systemic challenge with S pneumoniae. These data suggest that an IgM response to PPS vaccines is sufficient for conferring immunity.
在小鼠中，肺炎球菌多糖（PPS）疫苗可产生抗原特异性免疫球蛋白 M（IgM）和免疫球蛋白 G1、G2 和 G3。抗体和补体依赖性调理吞噬作用与 PPS 疫苗在体内诱导的保护作用相关。由于 IgM 是一种非常有效的免疫球蛋白亚型，可激活补体系统，因此我们评估了仅抗 PPS IgM 是否足以赋予肺炎链球菌保护性免疫。我们发现，用 Pneumovax 23 对仅能产生 IgM 的野生型和激活诱导的胞苷脱氨酶缺陷型小鼠进行免疫接种，可产生相当的抗 PPS IgM 并抵抗致死性系统性肺炎链球菌攻击。这些数据表明，对 PPS 疫苗的 IgM 反应足以赋予免疫力。
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