FIB-4指数可预测非酒精性脂肪性肝病患者的主要不良心血管事件及心血管死亡率。 - Suppr

FIB-4 Predicts MACE and Cardiovascular Mortality in Patients With Nonalcoholic Fatty Liver Disease.

作者信息

Chew Nicholas W S, Ng Cheng Han, Chan Kai En, Chee Douglas, Syn Nicholas, Tamaki Nobuharu, Muthiah Mark, Noureddin Mazen

机构信息

MBBS Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Cardiology, National University Heart Centre, National University Hospital, Singapore, Singapore.

MBBS Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

出版信息

Can J Cardiol. 2022 Nov;38(11):1779-1780. doi: 10.1016/j.cjca.2022.07.016. Epub 2022 Aug 3.

DOI:10.1016/j.cjca.2022.07.016

PMID:35933063

Abstract

摘要

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FIB-4 Predicts MACE and Cardiovascular Mortality in Patients With Nonalcoholic Fatty Liver Disease.FIB-4指数可预测非酒精性脂肪性肝病患者的主要不良心血管事件及心血管死亡率。

Can J Cardiol. 2022 Nov;38(11):1779-1780. doi: 10.1016/j.cjca.2022.07.016. Epub 2022 Aug 3.

Ability of Cytokeratin-18 Fragments and FIB-4 Index to Diagnose Overall and Mild Fibrosis Nonalcoholic Steatohepatitis in Japanese Nonalcoholic Fatty Liver Disease Patients.细胞角蛋白-18片段和FIB-4指数对日本非酒精性脂肪性肝病患者非酒精性脂肪性肝炎总体和轻度纤维化的诊断能力。

Dig Dis. 2017;35(6):521-530. doi: 10.1159/000480142. Epub 2017 Oct 17.

New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease.结合FIB-4指数和细胞角蛋白-18片段的新型评分系统用于预测非酒精性脂肪性肝病患者的脂肪性肝炎和肝纤维化

Biomarkers. 2018 May-Jun;23(4):328-334. doi: 10.1080/1354750X.2018.1425915. Epub 2018 Jan 19.

Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients With Nonalcoholic Fatty Liver Disease.肥胖和丙氨酸氨基转移酶水平对非酒精性脂肪性肝病患者无创性工具诊断晚期肝纤维化的准确性的影响。

Am J Gastroenterol. 2019 Jun;114(6):916-928. doi: 10.14309/ajg.0000000000000153.

Non-invasive fibrosis scoring systems can predict future metabolic complications and overall mortality in non-alcoholic fatty liver disease (NAFLD).非侵入性纤维化评分系统可预测非酒精性脂肪性肝病（NAFLD）患者未来的代谢并发症及总体死亡率。

Scand J Gastroenterol. 2019 Mar;54(3):328-334. doi: 10.1080/00365521.2019.1583366. Epub 2019 Mar 23.

Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration.在退伍军人健康管理局中识别非酒精性脂肪性肝病的肝纤维化程度。

Dig Dis Sci. 2018 Sep;63(9):2259-2266. doi: 10.1007/s10620-018-5123-3. Epub 2018 May 19.

Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease.纤维化-8 指数评分预测非酒精性脂肪性肝病患者显著纤维化的验证模型。

World J Gastroenterol. 2022 Apr 21;28(15):1563-1573. doi: 10.3748/wjg.v28.i15.1563.

Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease.纤维化 4 指数可独立预测非酒精性脂肪性肝病的主要不良心血管事件。

Am J Gastroenterol. 2022 Mar 1;117(3):453-461. doi: 10.14309/ajg.0000000000001606.

Accuracy of Noninvasive Scoring Systems in Assessing Risk of Death and Liver-Related Endpoints in Patients With Nonalcoholic Fatty Liver Disease.非酒精性脂肪性肝病患者死亡和肝脏相关终点风险评估的无创评分系统的准确性。

Clin Gastroenterol Hepatol. 2019 May;17(6):1148-1156.e4. doi: 10.1016/j.cgh.2018.11.030. Epub 2018 Nov 22.

Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese.在肥胖人群中，非酒精性脂肪性肝病的纤维化风险评分需要修改阈值。

Obes Surg. 2017 Jan;27(1):115-125. doi: 10.1007/s11695-016-2246-5.

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Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD.FIB-4和NFS对有无非酒精性脂肪性肝病（NAFLD）患者心血管事件的预后价值。

BMC Public Health. 2025 Aug 12;25(1):2747. doi: 10.1186/s12889-025-23883-x.

Non-invasive scoring systems of liver fibrosis predict prognosis in the cohort with myocardial infarction.肝纤维化的非侵入性评分系统可预测心肌梗死队列的预后。

Sci Rep. 2025 Jul 21;15(1):26499. doi: 10.1038/s41598-025-12583-6.

Glucagon-like peptide-1 receptor agonist in myocardial infarction and atherosclerotic cardiovascular disease risk reduction: a comprehensive meta-analysis of number needed to treat, efficacy and safety.胰高血糖素样肽-1受体激动剂在心肌梗死及降低动脉粥样硬化性心血管疾病风险中的应用：治疗所需人数、疗效及安全性的综合荟萃分析

Cardiovasc Diabetol. 2025 Jul 12;24(1):285. doi: 10.1186/s12933-025-02840-3.

Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction.急性ST段抬高型心肌梗死中Fibrosis-4与左心室动脉瘤形成风险之间的关联

Front Cardiovasc Med. 2025 Jun 13;12:1477206. doi: 10.3389/fcvm.2025.1477206. eCollection 2025.

Pravastatin reduces all-cause mortality in elderly individuals at risk of liver fibrosis: analysis of the PROSPER trial.普伐他汀降低有肝纤维化风险的老年人的全因死亡率：PROSPER试验分析

JHEP Rep. 2025 Feb 7;7(4):101337. doi: 10.1016/j.jhepr.2025.101337. eCollection 2025 Apr.

A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction.成年急性心肌梗死患者中瘦型2型糖尿病预后价值的性别分层分析

Cardiovasc Diabetol. 2025 Feb 7;24(1):59. doi: 10.1186/s12933-024-02552-0.

Risk of cardiovascular disease in elderly subjects with obesity and liver fibrosis and the potential benefit of statin treatment.肥胖和肝纤维化老年受试者的心血管疾病风险及他汀类药物治疗的潜在益处。

Eur J Clin Invest. 2025 Mar;55(3):e14368. doi: 10.1111/eci.14368. Epub 2024 Dec 5.

Sex differences in survival following acute coronary syndrome with and without standard modifiable risk factors.伴有和不伴有标准可改变风险因素的急性冠状动脉综合征患者生存情况的性别差异。

Clin Res Cardiol. 2025 Jun;114(6):681-689. doi: 10.1007/s00392-024-02563-7. Epub 2024 Nov 12.

Association Between Noninvasive Liver Fibrosis Scores and Heart Failure in a General Population.非侵入性肝纤维化评分与一般人群中心力衰竭的关系。

J Am Heart Assoc. 2024 Nov 19;13(22):e035371. doi: 10.1161/JAHA.123.035371. Epub 2024 Nov 7.

Non-Invasive Serum Markers of Non-Alcoholic Fatty Liver Disease Fibrosis: Potential Tools for Detecting Patients with Cardiovascular Disease.非酒精性脂肪性肝病纤维化的非侵入性血清标志物：检测心血管疾病患者的潜在工具。

Rev Cardiovasc Med. 2024 Sep 24;25(9):344. doi: 10.31083/j.rcm2509344. eCollection 2024 Sep.

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FIB-4 Predicts MACE and Cardiovascular Mortality in Patients With Nonalcoholic Fatty Liver Disease.

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