基于甘油三酯与葡萄糖指数的糖尿病预测
Diabetes mellitus prediction based on the triglyceride and glucose index.
作者信息
Campos Muñiz Carolina, León-García Plácido Enrique, Serrato Diaz Alejandra, Hernández-Pérez Elizabeth
机构信息
Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Iztapalapa, Ciudad de México, México.
Secretaría de Salud Pública del Distrito Federal, Servicios de Salud Pública del Distrito Federal, Ciudad de México, México.
出版信息
Med Clin (Barc). 2023 Mar 24;160(6):231-236. doi: 10.1016/j.medcli.2022.07.003. Epub 2022 Aug 4.
INTRODUCTION
In Mexico, type 2 Diabetes mellitus (DM2) presents epidemiological levels with a prevalence rate of 9.12% and with the highest overweight and obesity rates worldwide. To overcome this situation, strategies must be created focused on the identification of subjects at risk. The Triglyceride and Glucose (TyG) index, was created for the detection of insulin resistance, has recently been used in the prediction of DM. The objective of the present study was to determine the predictive power of the TyG index in a cohort from Mexico City.
METHODS
3195 patients were selected from a cohort of patients from the chronic degenerative area of the Health Centers of the Public Health Services of Mexico City. The ability of the TyG index in predicting diabetes was evaluated as: ln [Fasting triglycerides (mg/dl) x fasting glucose (mg/dl)/2]. after a follow-up of at least 4.5 years. A CHAID test was determined that was corroborated by a ROC test.
RESULTS
the value of the TyG index was significantly higher for patients who develop DM2. Values of AUC=0.934, 95% CI: 0.924-0.924. Obtaining a cut-off point of 9.45 in women; in men: DM2 AUC=0.824, 95% CI: 0.824-0.873, and cut-off point 9.12.
CONCLUSIONS
The TyG index is a good marker in the prediction of DM2. The CHAID determination is a useful tool in the prediction of DM2.
引言
在墨西哥，2型糖尿病（DM2）呈现出一定的流行病学水平，患病率为9.12%，且超重和肥胖率位居全球之首。为克服这一情况，必须制定聚焦于识别高危人群的策略。甘油三酯与葡萄糖（TyG）指数是为检测胰岛素抵抗而创建的，最近已用于糖尿病的预测。本研究的目的是确定TyG指数在墨西哥城一组人群中的预测能力。
方法
从墨西哥城公共卫生服务中心慢性病区的一组患者中选取3195例患者。TyG指数预测糖尿病的能力评估为：ln[空腹甘油三酯（mg/dl）×空腹血糖（mg/dl）/2]。经过至少4.5年的随访。确定了CHAID检验，并通过ROC检验进行了验证。
结果
发生DM2的患者TyG指数值显著更高。AUC值 = 0.934，95%置信区间：0.924 - 0.924。女性的截断点为9.45；男性中，DM2的AUC = 0.824，95%置信区间：0.824 - 0.873，截断点为9.12。
结论
TyG指数是预测DM2的良好指标。CHAID测定是预测DM2的有用工具。
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