Department of Neuroscience, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milano, Italy.
Università degli Studi di Milano, Milano, Italy.
Pediatr Neurol. 2022 Oct;135:1-3. doi: 10.1016/j.pediatrneurol.2022.06.021. Epub 2022 Jul 5.
Children presenting with complex febrile seizures (FS) have an increased risk of developing epilepsy. This study aimed to investigate the occurrence of complex seizures in children presenting with FS and those with both convulsions associated with mild gastroenteritis (CwG) and fever.
Children admitted to our Pediatric Emergency Department between January 2017 and April 2019 with seizures were enrolled in this cross-sectional study. Patients were grouped according to the etiology as FS and febrile CwG. FS classification criteria of simple FS and complex FS was applied to both groups to allow a comparison between them. Prevalence ratios (PRs) of complex seizures, estimated through a log binomial model, were used to compare the occurrence of complex seizures between the two groups, using the FS group as reference category.
A total of 294 patients were enrolled: 231 with FS and 63 with febrile CwG. Complex seizures occurred in 31 patients with FS (13.4%) and 21 patients (33.3%) with febrile CwG. The PR of complex seizures was 2.48 (95% confidence interval, 1.54 to 4.01).
Children with febrile CwG showed a higher rate of complex seizures when compared with those with FS.
表现为复杂热性惊厥（FS）的儿童发生癫痫的风险增加。本研究旨在调查表现为 FS 及伴有轻度胃肠炎相关惊厥（CwG）和发热的儿童中复杂惊厥的发生情况。
本横断面研究纳入了 2017 年 1 月至 2019 年 4 月期间在我院儿科急诊就诊的伴有惊厥的患儿。根据病因将患儿分为 FS 和发热性 CwG 两组。对两组患儿均应用单纯性 FS 和复杂性 FS 的 FS 分类标准进行分组，以便对两组进行比较。使用对数二项式模型估计复杂惊厥的患病率比（PR），将两组间复杂惊厥的发生情况进行比较，以 FS 组为参考类别。
共纳入 294 例患儿：FS 组 231 例，发热性 CwG 组 63 例。FS 组中有 31 例（13.4%）发生复杂惊厥，发热性 CwG 组中有 21 例（33.3%）发生复杂惊厥。复杂惊厥的 PR 为 2.48（95%置信区间，1.54 至 4.01）。
与 FS 患儿相比，发热性 CwG 患儿发生复杂惊厥的比率更高。
