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HNF4A Defines Molecular Subtypes and Vulnerability to Transforming Growth Factor β-Pathway Targeted Therapies in Cancers of the Distal Esophagus.

作者信息

Blum Andrew E, Ravillah Durgadevi, Katabathula Ramachandra M, Khalighi Sirvan, Varadan Vinay, Guda Kishore

机构信息

Division of Gastroenterology, Northeast Ohio Veteran Affairs Healthcare System, Cleveland, Ohio,; Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, and, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

出版信息

Gastroenterology. 2022 Nov;163(5):1457-1460. doi: 10.1053/j.gastro.2022.07.073. Epub 2022 Aug 4.

DOI:10.1053/j.gastro.2022.07.073
PMID:35934060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9613531/
Abstract
摘要

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本文引用的文献

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The role of transforming growth factor β in upper gastrointestinal cancers: A systematic review.转化生长因子 β 在上消化道癌症中的作用：系统评价。
Cancer Treat Rev. 2021 Nov;100:102285. doi: 10.1016/j.ctrv.2021.102285. Epub 2021 Sep 2.
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Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database.
原发性和转移性食管腺癌不同临床阶段的细胞状态和微环境
bioRxiv. 2025 Mar 3:2024.08.17.608386. doi: 10.1101/2024.08.17.608386.
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miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.miRNA-660-3p 通过负向调控 APOC1-TGFβ2 信号通路抑制胶质母细胞瘤的恶性程度。
Cancer Biol Ther. 2023 Dec 31;24(1):2281459. doi: 10.1080/15384047.2023.2281459. Epub 2023 Nov 19.
青年发病型食管腺癌的流行病学和结局：基于人群数据库的分析。
Cancer Epidemiol Biomarkers Prev. 2021 Jan;30(1):142-149. doi: 10.1158/1055-9965.EPI-20-0944. Epub 2020 Dec 11.
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Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas.谱系特异性表观基因组和基因组激活癌基因 HNF4A 促进胃肠腺癌。
Cancer Res. 2020 Jul 1;80(13):2722-2736. doi: 10.1158/0008-5472.CAN-20-0390. Epub 2020 Apr 24.
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Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state.鉴定食管腺癌及其癌前状态之间共享的原始肠转录因子网络。
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