Estevão Bianca M, Vilela Raquel R C, Geremias Isabella P, Zanoni Kassio P S, de Camargo Andrea S S, Zucolotto Valtencir
Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil.
Laboratory of Spectroscopy of Functional Materials, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil.
Photodiagnosis Photodyn Ther. 2022 Dec;40:103052. doi: 10.1016/j.pdpdt.2022.103052. Epub 2022 Aug 5.
Organically modified mesoporous silica nanoparticles (MSNs) containing Ir complexes (Ir1, Ir2 and Ir3) were successfully synthesized. These Ir-entrapped MCM41-COOH nanoparticles have shown relevant photophysical characteristics including high efficiency in the photoproduction and delivery of singlet oxygen (O), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that complex@MCM41-COOH are able to reduce cell proliferation after 10 min of blue-light irradiation in Hep-G2 liver cancer cells.
成功合成了含有铱配合物（Ir1、Ir2和Ir3）的有机改性介孔二氧化硅纳米颗粒（MSNs）。这些包载铱的MCM41-COOH纳米颗粒表现出相关的光物理特性，包括在单线态氧（O）的光产生和传递方面具有高效率，这对于光动力疗法（PDT）应用特别有前景。体外测试证明，在对Hep-G2肝癌细胞进行蓝光照射10分钟后，配合物@MCM41-COOH能够降低细胞增殖。
