Cardiac electrophysiologic actions of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid in the anesthetized dog.

Cardiac electrophysiologic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) were studied in pentobarbital anesthetized dogs. Doses of 0.5, 1 and 2 mg kg-1 i.v. produced a dose dependent slowing down of S-A and idioventricular pacemakers, increase in atrioventricular (A-V), atrial and ventricular refractoriness, and decrease in intra-atrial, A-V and intra-ventricular conduction. Retrograde ventriculoatrial conduction was affected only slightly. In dogs with A-V blockade BK 129 suppressed norepinephrine-induced acceleration of S-A and idioventricular rhythm and intra-ventricular conductivity. These results suggest that BK 129 may be an effective agent for treating cardiac arrhythmias.