关于：晚期非小细胞肺癌中PCR基因分型的不足：实时PCR IdyllaTM表皮生长因子受体（EGFR）突变检测未检测到外显子19的EGFR L747_A755delinsSS缺失，但循环肿瘤DNA（ctDNA）下一代测序（NGS）检测到该缺失，且该缺失对奥希替尼有反应。 - Suppr

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超能文献

Re: Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS Exon 19 deletion is not detected by the real-time PCR IdyllaTM EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib.

作者信息

Bennett Phil, Finall Alison, Medeiros Filomena, Gerrard Gareth, Taniere Phillipe

机构信息

Sarah Cannon Molecular Diagnostics, HCA Healthcare UK, London, United Kingdom.

Cellular Pathology, Swansea Bay University Health Board, Swansea, Wales, United Kingdom.

出版信息

Eur J Cancer. 2022 Oct;174:315-317. doi: 10.1016/j.ejca.2022.06.039. Epub 2022 Aug 4.

DOI:10.1016/j.ejca.2022.06.039

PMID:35934607

Abstract

摘要

相似文献

Re: Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS Exon 19 deletion is not detected by the real-time PCR IdyllaTM EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib.关于：晚期非小细胞肺癌中PCR基因分型的不足：实时PCR IdyllaTM表皮生长因子受体（EGFR）突变检测未检测到外显子19的EGFR L747_A755delinsSS缺失，但循环肿瘤DNA（ctDNA）下一代测序（NGS）检测到该缺失，且该缺失对奥希替尼有反应。

Eur J Cancer. 2022 Oct;174:315-317. doi: 10.1016/j.ejca.2022.06.039. Epub 2022 Aug 4.

Response to letter entitled: Re: 'Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib': Not looking back.对题为《回复：“晚期非小细胞肺癌中PCR基因分型的不足：实时PCR Idylla EGFR突变检测未检测到EGFR L747_A755delinsSS外显子19缺失，但ctDNA NGS检测到并对奥希替尼有反应”》的信的回复：不回头。

Eur J Cancer. 2022 Oct;174:318-320. doi: 10.1016/j.ejca.2022.06.040. Epub 2022 Aug 7.

Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib.晚期非小细胞肺癌中PCR基因分型的不足：实时PCR Idylla™ EGFR突变检测未检测到EGFR L747_A755delinsSS外显子19缺失，但通过ctDNA下一代测序检测到该缺失，且该缺失对奥希替尼有反应。

Eur J Cancer. 2022 May;166:38-40. doi: 10.1016/j.ejca.2022.02.007. Epub 2022 Mar 8.

The role of comprehensive analysis with circulating tumor DNA in advanced non-small cell lung cancer patients considered for osimertinib treatment.在考虑使用奥希替尼治疗的晚期非小细胞肺癌患者中，采用循环肿瘤 DNA 进行综合分析的作用。

Cancer Med. 2021 Jun;10(12):3873-3885. doi: 10.1002/cam4.3929. Epub 2021 May 12.

Circulating tumor DNA analysis of EGFR-mutant non-small cell lung cancer patients receiving osimertinib following previous tyrosine kinase inhibitor treatment.先前接受过酪氨酸激酶抑制剂治疗的表皮生长因子受体（EGFR）突变型非小细胞肺癌患者接受奥希替尼治疗后的循环肿瘤DNA分析

Lung Cancer. 2020 Jul;145:173-180. doi: 10.1016/j.lungcan.2020.04.039. Epub 2020 May 11.

Predicting osimertinib-treatment outcomes through EGFR mutant-fraction monitoring in the circulating tumor DNA of EGFR T790M-positive patients with non-small cell lung cancer (WJOG8815L).通过检测 EGFR T790M 阳性非小细胞肺癌患者循环肿瘤 DNA 中的 EGFR 突变等位基因丰度预测奥希替尼治疗效果（WJOG8815L）。

Mol Oncol. 2021 Jan;15(1):126-137. doi: 10.1002/1878-0261.12841. Epub 2020 Nov 17.

Patients with uncommon EGFR mutations also benefit from first-line osimertinib.具有罕见表皮生长因子受体（EGFR）突变的患者也能从一线使用奥希替尼中获益。

Nat Rev Clin Oncol. 2024 Feb;21(2):84. doi: 10.1038/s41571-023-00847-x.

Clearing of circulating tumour DNA predicts clinical response to osimertinib in EGFR mutated lung cancer patients.循环肿瘤 DNA 清除预测 EGFR 突变型肺癌患者对奥希替尼的临床反应。

Lung Cancer. 2020 May;143:67-72. doi: 10.1016/j.lungcan.2020.03.020. Epub 2020 Mar 19.

Brief Report: Evaluation of Molecular Profiling Strategies for Neoadjuvant Osimertinib in Stage IIIA EGFR-Mutant NSCLC.简短报告：ⅢA期表皮生长因子受体（EGFR）突变型非小细胞肺癌（NSCLC）新辅助奥希替尼分子分析策略的评估

Clin Lung Cancer. 2024 Jan;25(1):e58-e61. doi: 10.1016/j.cllc.2023.08.012. Epub 2023 Aug 30.

Osimertinib in Patients With Non-Small Cell Lung Cancer and Uncommon EGFR Mutations-Chasing Unicorns?奥希替尼用于非小细胞肺癌及罕见表皮生长因子受体（EGFR）突变患者——追逐独角兽？

JAMA Oncol. 2024 Jan 1;10(1):52-53. doi: 10.1001/jamaoncol.2023.5004.

引用本文的文献

Evaluation of the Idylla™ EGFR Mutation Test on formalin-fixed, paraffin-embedded tissue of human lung cancer.对人肺癌福尔马林固定、石蜡包埋组织进行Idylla™表皮生长因子受体（EGFR）突变检测的评估。

J Thorac Dis. 2024 Jan 30;16(1):40-50. doi: 10.21037/jtd-23-1293. Epub 2024 Jan 8.

Clinical application of liquid biopsy based on circulating tumor DNA in non-small cell lung cancer.基于循环肿瘤DNA的液体活检在非小细胞肺癌中的临床应用

Front Physiol. 2023 Jun 7;14:1200124. doi: 10.3389/fphys.2023.1200124. eCollection 2023.

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