晚期非小细胞肺癌中PCR基因分型的不足：实时PCR Idylla™ EGFR突变检测未检测到EGFR L747_A755delinsSS外显子19缺失，但通过ctDNA下一代测序检测到该缺失，且该缺失对奥希替尼有反应。 - Suppr

Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib.

作者信息

O'Sullivan Hazel, d'Arienzo Paolo D, Yousaf Nadia, Cui Wanyuan, Popat Sanjay

机构信息

Lung Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom.

Lung Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom; Thoracic Oncology, Institute of Cancer Research, London, United Kingdom.

出版信息

Eur J Cancer. 2022 May;166:38-40. doi: 10.1016/j.ejca.2022.02.007. Epub 2022 Mar 8.

DOI:10.1016/j.ejca.2022.02.007

PMID:35276501

Abstract

摘要

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Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib.晚期非小细胞肺癌中PCR基因分型的不足：实时PCR Idylla™ EGFR突变检测未检测到EGFR L747_A755delinsSS外显子19缺失，但通过ctDNA下一代测序检测到该缺失，且该缺失对奥希替尼有反应。

Eur J Cancer. 2022 May;166:38-40. doi: 10.1016/j.ejca.2022.02.007. Epub 2022 Mar 8.

Re: Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS Exon 19 deletion is not detected by the real-time PCR IdyllaTM EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib.关于：晚期非小细胞肺癌中PCR基因分型的不足：实时PCR IdyllaTM表皮生长因子受体（EGFR）突变检测未检测到外显子19的EGFR L747_A755delinsSS缺失，但循环肿瘤DNA（ctDNA）下一代测序（NGS）检测到该缺失，且该缺失对奥希替尼有反应。

Eur J Cancer. 2022 Oct;174:315-317. doi: 10.1016/j.ejca.2022.06.039. Epub 2022 Aug 4.

Response to letter entitled: Re: 'Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib': Not looking back.对题为《回复：“晚期非小细胞肺癌中PCR基因分型的不足：实时PCR Idylla EGFR突变检测未检测到EGFR L747_A755delinsSS外显子19缺失，但ctDNA NGS检测到并对奥希替尼有反应”》的信的回复：不回头。

Eur J Cancer. 2022 Oct;174:318-320. doi: 10.1016/j.ejca.2022.06.040. Epub 2022 Aug 7.

The role of comprehensive analysis with circulating tumor DNA in advanced non-small cell lung cancer patients considered for osimertinib treatment.在考虑使用奥希替尼治疗的晚期非小细胞肺癌患者中，采用循环肿瘤 DNA 进行综合分析的作用。

Cancer Med. 2021 Jun;10(12):3873-3885. doi: 10.1002/cam4.3929. Epub 2021 May 12.

Predicting osimertinib-treatment outcomes through EGFR mutant-fraction monitoring in the circulating tumor DNA of EGFR T790M-positive patients with non-small cell lung cancer (WJOG8815L).通过检测 EGFR T790M 阳性非小细胞肺癌患者循环肿瘤 DNA 中的 EGFR 突变等位基因丰度预测奥希替尼治疗效果（WJOG8815L）。

Mol Oncol. 2021 Jan;15(1):126-137. doi: 10.1002/1878-0261.12841. Epub 2020 Nov 17.

Circulating tumor DNA analysis of EGFR-mutant non-small cell lung cancer patients receiving osimertinib following previous tyrosine kinase inhibitor treatment.先前接受过酪氨酸激酶抑制剂治疗的表皮生长因子受体（EGFR）突变型非小细胞肺癌患者接受奥希替尼治疗后的循环肿瘤DNA分析

Lung Cancer. 2020 Jul;145:173-180. doi: 10.1016/j.lungcan.2020.04.039. Epub 2020 May 11.

Clearing of circulating tumour DNA predicts clinical response to osimertinib in EGFR mutated lung cancer patients.循环肿瘤 DNA 清除预测 EGFR 突变型肺癌患者对奥希替尼的临床反应。

Lung Cancer. 2020 May;143:67-72. doi: 10.1016/j.lungcan.2020.03.020. Epub 2020 Mar 19.

Comparison of epidermal growth factor receptor mutation detection turnaround times and concordance among real-time polymerase chain reaction, high-throughput next-generation sequencing and the Biocartis Idylla™ platforms in non-small cell lung carcinomas.实时聚合酶链反应、高通量下一代测序和 Biocartis Idylla™ 平台在非小细胞肺癌中表皮生长因子受体突变检测周转时间和一致性的比较。

Pathol Res Pract. 2021 Apr;220:153394. doi: 10.1016/j.prp.2021.153394. Epub 2021 Mar 3.

The presence and variant allele fraction of EGFR mutations in ctDNA and development of resistance.ctDNA 中 EGFR 突变的存在和变异等位基因分数与耐药性的发展。

Lung Cancer. 2019 May;131:86-89. doi: 10.1016/j.lungcan.2019.03.019. Epub 2019 Mar 20.

Plasma next generation sequencing and droplet digital PCR-based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent-line osimertinib.采用基于血浆下一代测序和液滴数字 PCR 的方法检测晚期肺癌患者在使用后续奥希替尼治疗后的表皮生长因子受体（EGFR）突变。

Thorac Cancer. 2019 Oct;10(10):1879-1884. doi: 10.1111/1759-7714.13154. Epub 2019 Aug 15.

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Feasibility analysis of rapid gene detection using intraoperative frozen tissues: comparison of intraoperative frozen tissues with paraffin-embedded tissues in epidermal growth factor receptor gene mutation detection of lung adenocarcinoma.术中冰冻组织快速基因检测的可行性分析：肺腺癌表皮生长因子受体基因突变检测中术中冰冻组织与石蜡包埋组织的比较。

J Cancer Res Clin Oncol. 2023 Oct;149(13):12025-12032. doi: 10.1007/s00432-023-05056-8. Epub 2023 Jul 8.

Performance of Ultra-Rapid Idylla™ EGFR Mutation Test in Non-Small-Cell Lung Cancer and Its Potential at Clinical Molecular Screening.超快速Idylla™表皮生长因子受体（EGFR）突变检测在非小细胞肺癌中的性能及其在临床分子筛查中的潜力

Cancers (Basel). 2023 May 7;15(9):2648. doi: 10.3390/cancers15092648.

The Role of Cell-Free DNA in Cancer Treatment Decision Making.游离DNA在癌症治疗决策中的作用。

Cancers (Basel). 2022 Dec 12;14(24):6115. doi: 10.3390/cancers14246115.

EGFR T751_I759delinsN Mutation in Exon19 Detected by NGS but Not by Real-Time PCR in a Heavily-Treated Patient with NSCLC.EGFR 外显子 19 中的 T751_I759delinsN 突变通过 NGS 检测到，但在经过大量治疗的 NSCLC 患者中通过实时 PCR 未检测到。

Int J Mol Sci. 2022 Nov 3;23(21):13451. doi: 10.3390/ijms232113451.

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Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib.

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