Windler E E, Bützow G H, Greten H
Atherosclerosis. 1987 Mar;64(1):63-70. doi: 10.1016/0021-9150(87)90055-4.
The catabolism of lipoproteins was measured in rats with a portacaval anastomosis and in intact control rats. Radioiodinated rat high density lipoproteins or human low density lipoproteins, the major cholesterol-bearing lipoproteins in rat or man respectively, were injected intravenously into rats. More than 90% of trace amounts of these lipoproteins were removed from plasma of rats with portacaval anastomosis and controls on standard chow at closely similar rates within 24 h. Also, [125I]high density lipoproteins left the plasma at comparable rates in controls and rats with portacaval anastomosis, whether fed with a cholesterol-free chow or a carbohydrate-rich lard chow. These dietary regimens were employed to avoid artifacts through a different development of the body weight in operated and control rats. A standard laboratory chow ad libitum led to weight loss in rats with portacaval anastomosis. Pair-fed with a cholesterol-free chow both groups of rats kept the same weight, but only with a carbohydrate-rich lard chow could the natural weight gain be achieved. In all rats with portacaval anastomosis liver weights were reduced and serum cholesterol decreased by 21-31% with the major change in high density lipoproteins. The findings suggest that cholesterol concentrations are not likely to be lowered in rats with portacaval anastomosis by enhanced lipoprotein catabolism.
在患有门腔静脉吻合术的大鼠和完整的对照大鼠中测量了脂蛋白的分解代谢。将放射性碘化的大鼠高密度脂蛋白或人低密度脂蛋白（分别是大鼠或人中主要携带胆固醇的脂蛋白）静脉注射到大鼠体内。在24小时内，这些脂蛋白的微量成分中超过90%以非常相似的速率从患有门腔静脉吻合术的大鼠和食用标准食物的对照大鼠的血浆中清除。此外，无论喂食无胆固醇食物还是富含碳水化合物的猪油食物，[125I]高密度脂蛋白在对照大鼠和患有门腔静脉吻合术的大鼠中以相当的速率离开血浆。采用这些饮食方案是为了避免因手术大鼠和对照大鼠体重的不同增长而产生假象。随意喂食标准实验室食物会导致患有门腔静脉吻合术的大鼠体重减轻。两组大鼠与无胆固醇食物配对喂养时体重保持相同，但只有喂食富含碳水化合物的猪油食物才能实现自然体重增加。在所有患有门腔静脉吻合术的大鼠中，肝脏重量减轻，血清胆固醇降低21%-31%，主要变化发生在高密度脂蛋白上。研究结果表明，门腔静脉吻合术大鼠不太可能通过增强脂蛋白分解代谢来降低胆固醇浓度。
