Yeh Hsiao-Yun, Wu Hung-Ta Hondar, Shen Hsiao-Chin, Li Tzu-Hao, Yang Ying-Ying, Lee Kuei-Chuan, Lin Yi-Hsuan, Huang Chia-Chang, Hou Ming-Chih
Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Endocr Connect. 2024 Jul 3;13(8). doi: 10.1530/EC-24-0089. Print 2024 Aug 1.
Previous studies have suggested that body mass index (BMI) should be considered when assessing the relationship between fatty liver (FL) and osteoporosis. The aim of this study was to investigate future fracture events in people with FL, focusing on the effect of BMI in both sexes.
This retrospective cohort study, spanning from 2011 to 2019, enrolled 941 people, including 441 women and 500 men, aged 50 years or older who underwent liver imaging (ultrasound, computed tomography, or magnetic resonance image) and dual-energy X-ray absorptiometry (for bone mineral density measurements). The study examined predictors of osteoporosis in both sexes and the effect of different ranges of BMI (18.5-24, 24-27, and ≥27 kg/m2) on the risk of future fracture events in FL patients.
The average follow-up period was 5.3 years for women and 4.2 years for men. Multivariate analysis identified age and BMI as independent risk factors of osteoporosis in both sexes. Each unit increase in BMI decreased the risk of osteoporosis by ≥10%. In both women and men with FL, a BMI of 24-27 kg/m2 offered protection against future fractures, compared to those without FL and with a BMI of 18.5-24 kg/m2.
The protective effect of a higher BMI against future fractures in middle-aged and elderly female and male patients with FL is not uniform and diminishes beyond certain BMI ranges.
先前的研究表明，在评估脂肪肝（FL）与骨质疏松症之间的关系时应考虑体重指数（BMI）。本研究的目的是调查FL患者未来的骨折事件，重点关注BMI在男女两性中的影响。
这项回顾性队列研究涵盖2011年至2019年，纳入了941名年龄在50岁及以上的人，其中包括441名女性和500名男性，他们接受了肝脏成像（超声、计算机断层扫描或磁共振成像）和双能X线吸收法（用于测量骨密度）。该研究检查了两性骨质疏松症的预测因素，以及不同BMI范围（18.5-24、24-27和≥27kg/m²）对FL患者未来骨折事件风险的影响。
女性的平均随访期为5.3年，男性为4.2年。多变量分析确定年龄和BMI为两性骨质疏松症的独立危险因素。BMI每增加一个单位，骨质疏松症风险降低≥10%。在患有FL的女性和男性中，与未患FL且BMI为18.5-24kg/m²的人相比，BMI为24-27kg/m²可预防未来骨折。
较高的BMI对中老年FL女性和男性患者未来骨折的保护作用并不一致，且在特定BMI范围之外会减弱。
