Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Western Veterinary Clinical Center, Chiba Prefectural Federated Agricultural Mutual Aid Association, Chiba, Japan.
J Vet Med Sci. 2022 Sep 21;84(10):1373-1376. doi: 10.1292/jvms.22-0249. Epub 2022 Aug 5.
Changes in the C-reactive protein (CRP) and 13,14-dihydro-15-keto-prostaglandin F (PGFM) concentrations of uterine lavage fluid were examined in cows given an intrauterine povidone-iodine (PI) infusion. The mean polymorphonuclear leukocyte (PMN) ratios (the ratio of PMN to total cells) and CRP concentration of uterine lavage fluid on the day after the treatment were significantly (P<0.05) greater in the PI infusion group (PMN: 53.0 ± 32.7%, CRP: 50.2 ± 32.3 ng/mL) than in the non-treatment control group (PMN: 7.9 ± 21.9%, CRP: 17.2 ± 5.9 ng/mL), whereas there was no significant difference in the mean PGFM concentration between the two groups. The present findings suggest that the uterine CRP level is a useful biomarker of local uterine inflammation in cows.
检测了向奶牛子宫内输注聚维酮碘（PI）后冲洗液中 C 反应蛋白（CRP）和 13,14-二氢-15-酮-前列腺素 F（PGFM）浓度的变化。治疗后第 1 天，PI 输注组子宫冲洗液中多形核白细胞（PMN）的平均比例（PMN 与总细胞的比值）和 CRP 浓度明显高于非治疗对照组（PMN：53.0±32.7%，CRP：50.2±32.3ng/mL）（P<0.05），而两组间 PGFM 的平均浓度无显著差异。本研究结果表明，子宫 CRP 水平是奶牛子宫局部炎症的有用生物标志物。
