Manns J G, Nkuuhe J R, Bristol F
Can J Comp Med. 1985 Oct;49(4):436-8.
Uterine fluid was obtained from eight clinical cases of pyometra with retained corpus luteum and nine additional samples of fluid were collected from animals slaughtered at an abattoir. These samples, along with uterine flushes from normal cows in their luteal phase were analyzed for prostaglandin of the F (PGF) and E (PGE) groups. Blood samples were also obtained from the clinical cases for analysis of 13,14-dihydro-15-keto PGF (PGFM) the major metabolite of PGF. Pyometrial exudate from clinical cases of abattoir samples had high concentrations of PGF (17.9 ng/mL) and PGE (33.2 ng/mL) and the total amount of PGF and PGE in the uterus was calculated to be several hundred times as great as in normal cows. Furthermore, clinical cases had elevated PGFM in their blood compared to that of controls, which suggests that at least some of the PGF was being absorbed from the uterus. These results are discussed in light of our current understanding of the maternal recognition of pregnancy in cattle.
从8例患有黄体滞留的子宫积脓临床病例中获取子宫液，并从屠宰场宰杀的动物中另外收集9份液体样本。这些样本，连同处于黄体期的正常母牛的子宫冲洗液，都进行了F组（PGF）和E组（PGE）前列腺素的分析。还从临床病例中采集了血样，用于分析PGF的主要代谢产物13,14 - 二氢 - 15 - 酮PGF（PGFM）。临床病例和屠宰场样本的子宫积脓渗出液中PGF（17.9 ng/mL）和PGE（33.2 ng/mL）浓度很高，子宫中PGF和PGE的总量经计算比正常母牛高出数百倍。此外，与对照组相比，临床病例血液中的PGFM升高，这表明至少有一些PGF正在从子宫中被吸收。结合我们目前对牛母体识别妊娠的理解对这些结果进行了讨论。
