Abdullah Ahmad H, Zahra Jalal A, Sabri Salim S, Awwadi Firas F, Hussein Ahmad Q, El-Abadelah Mustafa M
Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
Faculty of Pharmacy, Zarqa University, Zarqa 13132, Jordan.
Z Naturforsch C J Biosci. 2022 Aug 8;78(3-4):133-140. doi: 10.1515/znc-2022-0080. Print 2023 Mar 28.
Model -chloro--nitrothieno[2,3-]pyridazines incorporating 1-(aryl) entity appended with -methoxycarbonyl or trifluoromethyl group were prepared intramolecular cyclization of their respective -arylhydrazone precursors. Interaction of these substrates with '-(-fluorophenyl)benzothiohydrazide, in the presence of NEt, furnished the respective 1,3,4-thiadiazoline-pyridazine thiolate hybrids that were -methylated to produce the corresponding "sulfanyl" derivatives. Their structures were deduced from spectral data, and confirmed by single-crystal X-ray diffraction.
通过各自的芳基腙前体的分子内环化反应制备了含有连接有甲氧基羰基或三氟甲基的1-（芳基）实体的模型 - 氯 - 硝基噻吩并[2,3 - ]哒嗪。在三乙胺存在下，这些底物与' - （ - 氟苯基）苯硫代酰肼相互作用，得到各自的1,3,4 - 噻二唑啉 - 哒嗪硫醇盐杂化物，将其甲基化以产生相应的“硫烷基”衍生物。它们的结构由光谱数据推导得出，并通过单晶X射线衍射得到证实。
