Uppuluri Varuna Naga Venkata Arjun, Thukani Sathanantham Shanmugarajan, Bhimavarapu Sai Krishna, Elumalai Lokesh
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies (VISTAS), Chennai, 600 117, Tamil Nadu, India.
Adv Pharm Bull. 2022 May;12(3):437-448. doi: 10.34172/apb.2022.069. Epub 2021 Sep 14.
Tissue engineering is a novel regenerative approach in the medicinal field that promises the regeneration of damaged tissues. Moreover, tissue engineering involves synthetic and natural biomaterials that facilitate tissue or organ growth outside the body. Not surprisingly, the demand for polymer-based therapeutical approaches in skin tissue defects has increased at an effective rate, despite the pressing clinical need. Among the 3D scaffolds for tissue engineering and regeneration approaches, hydrogel scaffolds have shown significant importance for their use as 3D cross-linked scaffolds in skin tissue regeneration due to their ideal moisture retention property and porosity biocompatibility, biodegradable, and biomimetic characteristics. In this review, we demonstrated the choice of ideal biomaterials to fabricate the novel hydrogel scaffolds for skin tissue engineering. After a short introduction to the bioactive and drug-loaded polymeric hydrogels, the discussion turns to fabrication and characterisation techniques of the polymeric hydrogel scaffolds. In conclusion, we discuss the excellent wound healing potential of stem cell-loaded hydrogels and Nano-based approaches to designing hydrogel scaffolds for skin tissue engineering.
组织工程是医学领域一种新型的再生方法，有望实现受损组织的再生。此外，组织工程涉及合成和天然生物材料，可促进体外组织或器官生长。毫不奇怪，尽管临床需求迫切，但皮肤组织缺损中基于聚合物的治疗方法的需求仍在有效增长。在用于组织工程和再生方法的3D支架中，水凝胶支架因其理想的保湿性能、孔隙率、生物相容性、可生物降解性和仿生特性，作为3D交联支架在皮肤组织再生中的应用而显得尤为重要。在这篇综述中，我们展示了用于制造新型皮肤组织工程水凝胶支架的理想生物材料的选择。在简要介绍了生物活性和载药聚合物水凝胶之后，讨论转向了聚合物水凝胶支架的制造和表征技术。总之，我们讨论了载干细胞水凝胶的出色伤口愈合潜力以及用于皮肤组织工程的基于纳米的水凝胶支架设计方法。
