Whishaw I Q, Mittleman G, Bunch S T, Dunnett S B
Behav Brain Res. 1987 May;24(2):125-38. doi: 10.1016/0166-4328(87)90250-6.
Using the Morris swimming pool test of spatial navigation, medial caudate-putamen lesions in rats produce impairments in the acquisition and retention of both place and cue tasks, and impair the selection of normal navigation strategies. Also described are some novel features of spatial navigation behaviour displayed by control animals in cue and place tasks that provide insights into the performance of the caudate-putamen rats. Analyses of the swim patterns on postacquisition probe trials, in which the target platform was removed or relocated, showed that the strategy used by the caudate-putamen lesioned rats was dependent upon the task that they were required to solve. Control rats used a place strategy and distal visual cues to identify the location of the start points, the routes from the start points to the platform, and the location of the platform on both the cue and place tasks. The caudate-putamen lesioned rats used distal visual cues and a place strategy only to acquire the place task. They solved the cue task using a taxon strategy consisting of a combination of proximal and position response cues. The results suggest that when necessary, medial caudate-putamen lesioned rats, like normal rats, can use place strategies for spatial navigation, but if an alternate, perhaps simpler, taxon solution is available they seemingly ignore place information and navigate using the simpler strategy. The deficit, which has features of a neglect rather than a loss of ability per se, suggests that medial caudate-putamen neural systems are involved in the selection of alternative strategies in spatial navigation tasks.
通过使用莫里斯空间导航泳池试验发现，大鼠的内侧尾状核-壳核损伤会导致其在位置任务和线索任务的获取与保持方面出现障碍，并损害正常导航策略的选择。本文还描述了对照动物在线索任务和位置任务中所表现出的空间导航行为的一些新特征，这些特征有助于深入了解尾状核-壳核损伤大鼠的行为表现。对获取后探测试验（即移除或重新放置目标平台）中的游泳模式分析表明，尾状核-壳核损伤大鼠所采用的策略取决于它们需要解决的任务。对照大鼠在线索任务和位置任务中都使用位置策略和远端视觉线索来确定起点位置、从起点到平台的路线以及平台的位置。尾状核-壳核损伤大鼠仅在获取位置任务时使用远端视觉线索和位置策略。它们通过一种由近端和位置反应线索组合而成的分类策略来解决线索任务。结果表明，必要时，内侧尾状核-壳核损伤大鼠与正常大鼠一样，可以使用位置策略进行空间导航，但如果有另一种可能更简单的分类解决方案，它们似乎会忽略位置信息并使用更简单的策略进行导航。这种缺陷具有忽视而非能力丧失本身的特征，这表明内侧尾状核-壳核神经系统参与空间导航任务中替代策略的选择。
