Guo Ping, Fang Yu, Feng Ming, Zhao Xudong, Wang Shikai, Qian Mincai, Huang Juanjuan, Chen Huanxin
Department of Psychiatry, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, China.
Department of Anesthesiology, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, China.
Front Psychiatry. 2022 Jul 22;13:803220. doi: 10.3389/fpsyt.2022.803220. eCollection 2022.
Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants. Previous studies have shown that prazosin, an α1-adrenergic receptor antagonist, can help eliminate nightmares and improve sleep quality and suicidal ideation in PTSD patients. This case report presents that prazosin had a rapid antidepressant effect in a female adolescent PTSD patient with treatment-resistant depression (TRD). Prazosin improved not only depression symptoms but also sleep quality, suicidal ideation, and cognitive function. Prazosin was well tolerated without obvious adverse effects. Our preliminary study suggests that further clinical trials are needed to determine the efficacy and safety of prazosin in treating PTSD patients with comorbid TRD.
童年期的心理创伤可导致创伤后应激障碍（PTSD），并伴有长期的共病性抑郁，而传统抗抑郁药对此疗效不佳。先前的研究表明，α1肾上腺素能受体拮抗剂哌唑嗪有助于消除PTSD患者的噩梦，改善睡眠质量和自杀观念。本病例报告显示，哌唑嗪对一名患有难治性抑郁症（TRD）的女性青少年PTSD患者具有快速抗抑郁作用。哌唑嗪不仅改善了抑郁症状，还改善了睡眠质量、自杀观念和认知功能。哌唑嗪耐受性良好，无明显不良反应。我们的初步研究表明，需要进一步的临床试验来确定哌唑嗪治疗合并TRD的PTSD患者的疗效和安全性。
