Malone Andrew, Gallagher Sean, Saidi Jemil, Rizq Gina, O'Dowd Enda, Vallence Derek, Hameed Aamir
Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland.
Medical Device Design, National College of Art and Design, Dublin, Ireland.
Front Cardiovasc Med. 2022 Jul 22;9:910120. doi: 10.3389/fcvm.2022.910120. eCollection 2022.
In this work, a novel mock circulatory loop (MCL) is presented that is capable of simulating both healthy cardiac function and Heart Failure with preserved Ejection Fraction (HFpEF). This MCL differs from others presented in the literature as it features two independently actuated heart chambers, representing the left atrium and the left ventricle. This is an important improvement over other designs as it allows for potential HFpEF treatments to be examined, not just in relation to their effect on the left ventricle but also on the left atrium. The aim of this work was to show that novel MCL designs could be developed to allow for testing of new mechanical circulatory support devices for the treatment of HFpEF. Two loop configurations are presented, one featuring hard PVC cylindrical chambers and one that features soft silicone chambers which are anatomically analogous to the native heart. We show that both MCLs are capable of simulating the onset of HFpEF with a sustained increase in diastolic pressure of 62.03% and a sustained decrease in end diastolic volume (EDV) of 14.24%.
在这项工作中，提出了一种新型模拟循环回路（MCL），它能够模拟健康心脏功能以及射血分数保留的心力衰竭（HFpEF）。该MCL与文献中提出的其他模型不同，它具有两个独立驱动的心脏腔室，分别代表左心房和左心室。这是相对于其他设计的一项重要改进，因为它不仅可以研究潜在的HFpEF治疗方法对左心室的影响，还可以研究其对左心房的影响。这项工作的目的是表明，可以开发新型MCL设计，以便测试用于治疗HFpEF的新型机械循环支持装置。文中介绍了两种回路配置，一种采用硬聚氯乙烯圆柱形腔室，另一种采用与天然心脏在解剖学上相似的软硅胶腔室。我们表明，这两种MCL都能够模拟HFpEF的发作，舒张压持续升高62.03%，舒张末期容积（EDV）持续降低14.24%。
