Mathur Anurag, Ma Zhen, Loskill Peter, Jeeawoody Shaheen, Healy Kevin E
Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Bioscience (QB3), Berkeley, CA 94720, USA.
Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA.
Adv Drug Deliv Rev. 2016 Jan 15;96:203-13. doi: 10.1016/j.addr.2015.09.011. Epub 2015 Sep 30.
Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.
心血管疾病是全球主要的死亡原因。要实现下一阶段的潜在治疗策略和更好的预后工具，需要跨学科领域的共同努力。基于生物材料的心脏组织模型正在彻底改变临床前研究和转化应用领域。体外心脏组织建模的目标是创建人类心肌的生理功能模型，由于人类心脏的复杂结构和功能，这是一项艰巨的任务。本综述描述了使用生物材料和生物启发平台在体外心脏模型领域取得的进展。在过去十年中，该领域取得了长足的进步，我们设想其在药物筛选、疾病建模和精准医学领域的应用。
