Kalas Ammar, Hassan Abdelrahman, Alkhalifa Oumar, Dali Majd, Shaheen Fawaz
College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, SAU.
Internal Medicine, King Saud Hospital, Unayzah, SAU.
Cureus. 2022 Jul 5;14(7):e26568. doi: 10.7759/cureus.26568. eCollection 2022 Jul.
Factor V and VIII deficiency (F5F8D) is a rare coagulopathy; it's an autosomal recessive condition. This case report is about of 15-year-old unmarried Saudi female, who presented with a complaint of pain in the lower abdomen. Complete blood count and coagulation profile revealed low hemoglobin and prolongation of activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR). The deficiency of factor V and factor VIII was confirmed with factor test revealing reduced activities of factor V and VIII Combined deficiency of factors V and VIII should be considered in differential diagnoses of patients with prolonged INR, PT, and aPTT. Medical management is reserved for those who present with significant bleeding.
因子Ⅴ和Ⅷ缺乏症（F5F8D）是一种罕见的凝血病，为常染色体隐性疾病。本病例报告讲述的是一名15岁未婚沙特女性，她因下腹部疼痛前来就诊。全血细胞计数和凝血指标显示血红蛋白水平低，活化部分凝血活酶时间（aPTT）、凝血酶原时间（PT）和国际标准化比值（INR）延长。通过因子检测证实因子Ⅴ和因子Ⅷ缺乏，该检测显示因子Ⅴ和Ⅷ活性降低。对于INR、PT和aPTT延长的患者，鉴别诊断时应考虑因子Ⅴ和Ⅷ联合缺乏的情况。对于出现严重出血的患者，应采取药物治疗。
