Department of Health Management, Aerospace Center Hospital, Beijing 10089, China.
China Aerospace Academy of Systems Science and Engineering, Beijing 100037, China.
Comput Math Methods Med. 2022 Jul 29;2022:2123162. doi: 10.1155/2022/2123162. eCollection 2022.
To observe the effect of intestinal probiotics in the treatment of nonalcoholic fatty liver disease (NAFLD) and the effect on liver function and inflammatory factors.
34 healthy rats were selected for the study and divided into 10 rats in the control group, 12 rats in the model group, and 12 rats in the treatment group according to the random number table method. The control group was given behavioral and lifestyle interventions, and the treatment group was given Bifidobacterium minus Black enteric capsules 5 g/(kg-d) by strong feeding method on the basis of the control group. The fatty liver index (FLI), liver ultrasound examination results, liver function, and inflammatory factor levels were compared among the three groups. After 8 weeks of treatment, there were statistically significant differences between the FLI values and liver ultrasound results of the three groups, and the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triacylglycerol (TG), and total cholesterol (TC) levels of the observation group were lower than those of the control group and the model group. The levels of serum high molecular weight lipocalin (HMW-APN) and interleukin 22 (IL-22) in the observation group were higher than those in the control group, and the levels of tumor necrosis factor- (TNF-) were lower than those in the control and model groups, and the differences were statistically significant ( < 0.05).
Intestinal probiotics can improve the clinical efficacy of patients with NAFLD, improve liver function, and alleviate the inflammatory response, in order to provide a theoretical basis for the clinical treatment of patients with NAFLD.
观察肠道益生菌治疗非酒精性脂肪性肝病（NAFLD）的效果及对肝功能和炎症因子的影响。
选择 34 只健康大鼠进行研究，按随机数字表法分为对照组 10 只、模型组 12 只、治疗组 12 只。对照组给予行为及生活方式干预，治疗组在对照组基础上采用强饲法给予双歧杆菌 minus 黑肠球菌胶囊 5 g/（kg·d）。比较三组大鼠的脂肪肝指数（FLI）、肝脏超声检查结果、肝功能及炎症因子水平。治疗 8 周后，三组 FLI 值及肝脏超声结果比较差异有统计学意义，观察组血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、三酰甘油（TG）、总胆固醇（TC）水平均低于对照组和模型组，血清高分子量脂联素（HMW-APN）和白细胞介素 22（IL-22）水平高于对照组，肿瘤坏死因子-（TNF-）水平低于对照组和模型组，差异均有统计学意义（<0.05）。
肠道益生菌可提高 NAFLD 患者的临床疗效，改善肝功能，减轻炎症反应，为临床治疗 NAFLD 患者提供理论依据。
