Huang Chun-Ming, Tsai Hsiang-Lin, Chen Yen-Cheng, Huang Ching-Wen, Li Ching-Chun, Su Wei-Chih, Chang Tsung-Kun, Yeh Yung-Sung, Chen Po-Jung, Huang Ming-Yii, Wang Jaw-Yuan
Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Front Oncol. 2022 Jul 22;12:889658. doi: 10.3389/fonc.2022.889658. eCollection 2022.
Colorectal cancer (CRC) is a global public health concern because of its high prevalence and mortality. Although radiotherapy is a key method for treating CRC, radioresistance is an obstacle to radiotherapy use. The molecular mechanisms underlying the radioresistance of CRC remain unclear. Increasing evidence has revealed the multiple regulatory functions of non-coding RNAs (ncRNAs) in numerous malignancies, including CRC. Several ncRNAs have been reported to be involved in the determination of radiosensitivity of CRC cells, and some have excellent potential to be prognostic biomarkers or therapeutic targets in CRC treatment. The present review discusses the biological functions and underlying mechanisms of ncRNAs (primarily lncRNA, miRNA, and circRNA) in the regulation of the radiosensitivity of CRC. We also evaluate studies that examined ncRNAs as biomarkers of response to radiation and as therapeutic targets for enhancing radiosensitivity.
由于结直肠癌（CRC）的高发病率和死亡率，它已成为一个全球公共卫生问题。尽管放射治疗是治疗CRC的关键方法，但放射抗性是放射治疗应用的一个障碍。CRC放射抗性的分子机制仍不清楚。越来越多的证据揭示了非编码RNA（ncRNAs）在包括CRC在内的众多恶性肿瘤中的多种调控功能。据报道，几种ncRNAs参与了CRC细胞放射敏感性的决定，并且一些在CRC治疗中具有作为预后生物标志物或治疗靶点的巨大潜力。本综述讨论了ncRNAs（主要是lncRNA、miRNA和circRNA）在调节CRC放射敏感性中的生物学功能和潜在机制。我们还评估了将ncRNAs作为辐射反应生物标志物和增强放射敏感性治疗靶点的研究。
