State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Department of Pharmacology, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmacol Ther. 2021 Oct;226:107868. doi: 10.1016/j.pharmthera.2021.107868. Epub 2021 Apr 23.
Colorectal cancer (CRC) is one of malignant afflictions burdening people worldwide, mainly caused by shortages of effective medical intervention and poorly mechanistic understanding of the pathogenesis of CRC. Non-coding RNAs (ncRNAs) are a type of heterogeneous transcripts without the capability of coding protein, but have the potency of regulating protein-coding gene expression. Autophagy is an evolutionarily conserved catabolic process in which cytoplasmic contents are delivered to cellular lysosomes for degradation, resulting in the turnover of cellular components and producing energy for cell functions. A growing body of evidence reveals that ncRNAs, autophagy, and the crosstalks of ncRNAs and autophagy play intricate roles in the initiation, progression, metastasis, recurrence and therapeutic resistance of CRC, which confer ncRNAs and autophagy to serve as clinical biomarkers and therapeutic targets for CRC. In this review, we sought to delineate the complicated roles of ncRNAs, mainly including miRNAs, lncRNAs and circRNAs, in the pathogenesis of CRC, particularly focus on the regulatory role of ncRNAs in CRC-related autophagy, attempting to shed light on the complex pathological mechanisms, involving ncRNAs and autophagy, responsible for CRC tumorigenesis and development, so as to underpin the ncRNAs- and autophagy-based therapeutic strategies for CRC in clinical setting.
结直肠癌（CRC）是困扰全球人类的恶性疾病之一，主要是由于缺乏有效的医学干预措施和对 CRC 发病机制的理解不足所致。非编码 RNA（ncRNA）是一种无编码蛋白能力的异质性转录本，但具有调节蛋白编码基因表达的能力。自噬是一种进化上保守的分解代谢过程，其中细胞质内容物被递送到细胞溶酶体进行降解，导致细胞成分的周转，并为细胞功能产生能量。越来越多的证据表明，ncRNA、自噬以及 ncRNA 和自噬的串扰在 CRC 的发生、进展、转移、复发和治疗耐药性中发挥着复杂的作用，这使得 ncRNA 和自噬成为 CRC 的临床生物标志物和治疗靶点。在这篇综述中，我们试图描绘 ncRNA（主要包括 miRNAs、lncRNAs 和 circRNAs）在 CRC 发病机制中的复杂作用，特别是重点关注 ncRNA 在 CRC 相关自噬中的调节作用，试图阐明涉及 ncRNA 和自噬的复杂病理机制，这些机制导致 CRC 肿瘤的发生和发展，从而为基于 ncRNA 和自噬的 CRC 治疗策略提供理论基础。
