İnce Yusufoğlu Selen, Olcay Keziban
Department of Endodontics, Faculty of Dentistry, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Department of Endodontics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
J Dent Res Dent Clin Dent Prospects. 2022 Winter;16(1):70-75. doi: 10.34172/joddd.2022.011. Epub 2022 May 29.
This study aimed to investigate the effects of different final irrigation solutions on postoperative pain following root canal treatment. Eighty-nine nonvital premolar and molar teeth with periapical lesions (PAI: 3‒4) without any clinical symptoms were included. The patients were randomly assigned to three groups according to the final irrigation solutions used: G1: 2 mL of Qmix (n=29), G2: 2 mL of 17% ethylenediaminetetraacetic acid (EDTA) (n=30), and G3: 2 mL of 2% chlorhexidine gluconate (CHX) (n=30). All the patients were prescribed 100 mg of flurbiprofen to use as needed for pain. The patients were asked to rate their pain status according to the verbal rating scale at 12, 24, 48, and 72 hours, and one week. The data were analyzed using Pearson's chi-squared test, Fisher's exact test, and chi-squared analysis with Monte Carlo simulation. The significance level was set at ≤0.05. No significant differences were observed in postoperative pain rates at 12, 48, and 72 hours and one week (>0.05). However, in the Qmix group, a significantly lower pain level was observed at 24 hours with EDTA and CHX (=0.019). The rate of mild pain in the EDTA group at 72 hours (18.8%) was significantly higher in premolar teeth than in molar teeth (=0.012). The moderate pain level in the EDTA group at 12 hours was significantly higher in those>60 years of age (=0.008). The use of Qmix as an irrigation solution resulted in lower postoperative pain levels at 24 hours compared to other solutions. Therefore, Qmix can be considered a proper final irrigation solution in endodontic treatment regarding postoperative pain.
本研究旨在探讨不同的根管冲洗液对根管治疗术后疼痛的影响。纳入89颗患有根尖周病变（PAI：3-4）且无任何临床症状的无活力前磨牙和磨牙。根据所使用的根管冲洗液，将患者随机分为三组：G1组：2 mL Qmix（n = 29），G2组：2 mL 17%乙二胺四乙酸（EDTA）（n = 30），G3组：2 mL 2%葡萄糖酸氯己定（CHX）（n = 30）。所有患者均被开具100 mg氟比洛芬，按需用于止痛。要求患者在12、24、48和72小时以及1周时根据视觉模拟评分法对其疼痛状况进行评分。采用Pearson卡方检验、Fisher精确检验以及带有蒙特卡洛模拟的卡方分析对数据进行分析。显著性水平设定为≤0.05。在12、48和72小时以及1周时，术后疼痛发生率未观察到显著差异（>0.05）。然而，在Qmix组中，24小时时观察到的疼痛程度明显低于EDTA组和CHX组（P = 0.019）。EDTA组在72小时时前磨牙的轻度疼痛发生率（18.8%）显著高于磨牙（P = 0.012）。EDTA组在12小时时年龄>60岁者的中度疼痛程度显著更高（P = 0.008）。与其他冲洗液相比，使用Qmix作为冲洗液在24小时时术后疼痛程度更低。因此，就术后疼痛而言，Qmix可被视为根管治疗中一种合适的根管冲洗液。
