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乳房术后脂肪坏死的治疗算法——再探讨

Treatment Algorithm of Postsurgical Fat Necrosis of the Breast-Revisited.

作者信息

Haran Oriana, Legarda Carolina, Gofstein Dina, Adelson Dana, Singolda Roei, Madah Ehab, Arad Ehud, Grush Andrew E, Barnea Yoav

机构信息

Department of Plastic and Reconstructive Surgery, Tel-Aviv Sourasky Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

出版信息

Semin Plast Surg. 2022 Jun 13;36(2):94-100. doi: 10.1055/s-0042-1750435. eCollection 2022 May.

DOI:10.1055/s-0042-1750435
PMID:35937435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9352384/
Abstract

Fat necrosis is a common complication of breast surgery, with the potential to cause both functional and aesthetic repercussions that can affect patient satisfaction. Although several fat necrosis classification systems have been proposed, fat necrosis management varies widely across institutions, requiring revisiting of existing treatment protocols. We evaluated the postoperative outcomes on 335 breasts following either breast reduction or reconstruction with deep inferior epigastric perforator (DIEP) flaps at our institution between 2016 and 2020, with particular attention to the development of fat necrosis and the need for subsequent surgical intervention. Fat necrosis was diagnosed in 36 (10.74%) breasts, of which 16 (44.4%) were surgically removed and 20 (55.5%) were conservatively managed. Time of fat necrosis diagnosis: early (≤one-month after breast surgery) or late (>1 month) was the only variable associated with surgical intervention. Fat necrosis management should be approached on a case-by-case basis. Whenever possible, conservative management with regular clinical and radiological follow-up, and patient reassurance, should be pursued even for large masses, in the absence of concomitant complications.

摘要

脂肪坏死是乳腺手术的常见并发症,有可能导致功能和美学方面的不良影响,进而影响患者满意度。尽管已经提出了几种脂肪坏死分类系统,但各机构对脂肪坏死的处理方式差异很大,因此需要重新审视现有的治疗方案。我们评估了2016年至2020年期间在我院接受乳房缩小术或采用腹壁下深动脉穿支(DIEP)皮瓣进行乳房重建的335例乳房的术后结果,特别关注脂肪坏死的发生情况以及后续手术干预的必要性。36例(10.74%)乳房被诊断为脂肪坏死,其中16例(44.4%)接受了手术切除,20例(55.5%)接受了保守治疗。脂肪坏死诊断时间:早期(乳房手术后≤1个月)或晚期(>1个月)是与手术干预相关的唯一变量。脂肪坏死的处理应根据具体情况进行。只要有可能,即使是对于较大的肿块,在没有并发其他并发症的情况下,也应采用定期临床和影像学随访以及安抚患者的保守治疗方法。

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1
Treatment Algorithm of Postsurgical Fat Necrosis of the Breast-Revisited.乳房术后脂肪坏死的治疗算法——再探讨
Semin Plast Surg. 2022 Jun 13;36(2):94-100. doi: 10.1055/s-0042-1750435. eCollection 2022 May.
2
Fat necrosis in free transverse rectus abdominis myocutaneous and deep inferior epigastric perforator flaps.游离腹直肌肌皮瓣和腹壁下深动脉穿支皮瓣中的脂肪坏死
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Intraoperative Indocyanine Green Angiography for Fat Necrosis Reduction in the Deep Inferior Epigastric Perforator (DIEP) Flap.术中吲哚菁绿血管造影在腹壁下动脉穿支皮瓣(DIEP)脂肪坏死减少中的应用
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Fat necrosis in deep inferior epigastric perforator flaps: an ultrasound-based review of 202 cases.深部腹壁下动脉穿支皮瓣中的脂肪坏死:202 例基于超声的回顾性研究。
Plast Reconstr Surg. 2009 Dec;124(6):1754-1758. doi: 10.1097/PRS.0b013e3181bf7e03.
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Does post-mastectomy radiotherapy affect the outcome and prevalence of complications in immediate DIEP breast reconstruction? A prospective cohort study.乳房切除术后放疗是否会影响即刻腹壁下动脉穿支皮瓣乳房重建的结局及并发症发生率?一项前瞻性队列研究。
J Plast Reconstr Aesthet Surg. 2015 Oct;68(10):1379-85. doi: 10.1016/j.bjps.2015.06.003. Epub 2015 Jun 12.
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Comparison of irradiated versus nonirradiated DIEP flaps in patients undergoing immediate bilateral DIEP reconstruction with unilateral postmastectomy radiation therapy (PMRT).接受单侧乳房切除术后放射治疗(PMRT)并立即进行双侧腹壁下动脉穿支(DIEP)皮瓣重建的患者中,接受照射与未接受照射的DIEP皮瓣的比较。
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Muscle-sparing TRAM flap does not protect breast reconstruction from postmastectomy radiation damage compared with the DIEP flap.相较于 DIEP 皮瓣,保留肌肉的横形腹直肌肌皮瓣并不能保护乳房重建免受乳腺癌根治术后放疗的损害。
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Perforator number predicts fat necrosis in a prospective analysis of breast reconstruction with free TRAM, DIEP, and SIEA flaps.前瞻性分析游离 TRAM、DIEP 和 SIEA 皮瓣乳房重建术后脂肪坏死与穿支血管数量的关系。
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Increased Flap Weight and Decreased Perforator Number Predict Fat Necrosis in DIEP Breast Reconstruction.腹壁下动脉穿支皮瓣乳房重建术中皮瓣重量增加和穿支数量减少预示脂肪坏死
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Perfusion-related complications are similar for DIEP and muscle-sparing free TRAM flaps harvested on medial or lateral deep inferior epigastric Artery branch perforators for breast reconstruction.在乳房重建中,使用内侧或外侧腹壁下动脉穿支游离 DIEP 和保留肌肉的游离 TRAM 皮瓣时,与灌注相关的并发症相似。
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引用本文的文献

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Forgotten Surgical Sponge Mimicking Fat Necrosis Following Breast Reduction Surgery.乳房缩小术后被遗忘的手术海绵酷似脂肪坏死
Plast Reconstr Surg Glob Open. 2025 Jul 22;13(7):e7007. doi: 10.1097/GOX.0000000000007007. eCollection 2025 Jul.

本文引用的文献

1
Fat necrosis in the Breast: A systematic review of clinical.乳房脂肪坏死:临床的系统评价。
Lipids Health Dis. 2019 Jun 11;18(1):139. doi: 10.1186/s12944-019-1078-4.
2
Breast Reduction and Mastopexy for Repair of Asymmetry After Breast Conservation Therapy: Lessons Learned.乳房缩小术和乳房成形术修复保乳治疗后不对称:经验教训。
Aesthetic Plast Surg. 2019 Jun;43(3):600-607. doi: 10.1007/s00266-019-01338-0. Epub 2019 Feb 25.
3
Defining fat necrosis in plastic surgery.整形手术中脂肪坏死的定义。
Plast Reconstr Surg. 2014 Dec;134(6):1202-1212. doi: 10.1097/PRS.0000000000000700.
4
Increased Flap Weight and Decreased Perforator Number Predict Fat Necrosis in DIEP Breast Reconstruction.腹壁下动脉穿支皮瓣乳房重建术中皮瓣重量增加和穿支数量减少预示脂肪坏死
Plast Reconstr Surg Glob Open. 2013 Jun 7;1(2):1-7. doi: 10.1097/GOX.0b013e318294e41d. eCollection 2013 May.
5
Chronic inflammation and progressive calcification as a result of fat necrosis: the worst outcome in fat grafting.慢性炎症和脂肪坏死导致的进行性钙化:脂肪移植的最坏结果。
Plast Reconstr Surg. 2014 May;133(5):1064-1072. doi: 10.1097/PRS.0000000000000097.
6
A classification system for fat necrosis in autologous breast reconstruction.自体乳房重建中脂肪坏死的分类系统。
Ann Plast Surg. 2013 May;70(5):553-6. doi: 10.1097/SAP.0b013e31827ead1b.
7
Fat necrosis in autologous abdomen-based breast reconstruction: a systematic review.自体腹部乳房再造中的脂肪坏死:系统评价。
Plast Reconstr Surg. 2013 Mar;131(3):443-452. doi: 10.1097/PRS.0b013e31827c6dc2.
8
Sequelae of fat grafting postmastectomy: an algorithm for management of fat necrosis.乳房切除术后脂肪移植的后遗症:脂肪坏死的处理算法
Eplasty. 2012;12:e53. Epub 2012 Dec 4.
9
Fat necrosis in deep inferior epigastric perforator flaps: an ultrasound-based review of 202 cases.深部腹壁下动脉穿支皮瓣中的脂肪坏死:202 例基于超声的回顾性研究。
Plast Reconstr Surg. 2009 Dec;124(6):1754-1758. doi: 10.1097/PRS.0b013e3181bf7e03.
10
Factors predicting free flap complications in head and neck reconstruction.预测头颈部重建中游离皮瓣并发症的因素。
J Plast Reconstr Aesthet Surg. 2006;59(7):737-42. doi: 10.1016/j.bjps.2005.11.013. Epub 2006 Feb 21.