• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation.

作者信息

Harryvan T J, Hawinkels L J A C, Östman A, Ten Dijke P, Strell C, Hornsveld M

机构信息

Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

出版信息

Gastro Hep Adv. 2022;1(4):678-681. doi: 10.1016/j.gastha.2022.04.019.

DOI:10.1016/j.gastha.2022.04.019
PMID:35937541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9340885/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2957/11308561/3a0df935a150/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2957/11308561/b0cc8f66e1b6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2957/11308561/3a0df935a150/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2957/11308561/b0cc8f66e1b6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2957/11308561/3a0df935a150/gr2.jpg

相似文献

1
A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation.一种用于研究促结缔组织增生和肌成纤维细胞癌相关成纤维细胞分化的新型胰腺癌微肿瘤模型。
Gastro Hep Adv. 2022;1(4):678-681. doi: 10.1016/j.gastha.2022.04.019.
2
Myofibroblastic cancer-associated fibroblast subtype heterogeneity in pancreatic cancer.胰腺癌中肌成纤维细胞癌相关成纤维细胞亚型的异质性
J Surg Oncol. 2024 Apr;129(5):860-868. doi: 10.1002/jso.27582. Epub 2024 Jan 17.
3
Periostin- and podoplanin-positive cancer-associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma.骨膜蛋白和 podoplanin 阳性的癌相关成纤维细胞亚型协同作用，在侵袭性胰腺腺癌中塑造炎症肿瘤微环境。
J Pathol. 2022 Dec;258(4):408-425. doi: 10.1002/path.6011. Epub 2022 Oct 21.
4
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma.IL1 诱导的 JAK/STAT 信号被 TGFβ拮抗，从而塑造胰腺导管腺癌中 CAF 的异质性。
Cancer Discov. 2019 Feb;9(2):282-301. doi: 10.1158/2159-8290.CD-18-0710. Epub 2018 Oct 26.
5
Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology.Prrx1 调控的间质可塑性驱动侵袭性胰腺癌生物学。
Gastroenterology. 2021 Jan;160(1):346-361.e24. doi: 10.1053/j.gastro.2020.09.010. Epub 2020 Sep 30.
6
Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines.缺氧增强了由胰腺癌细胞衍生的细胞因子促进的炎症成纤维细胞表型。
Cancer Res. 2023 May 15;83(10):1596-1610. doi: 10.1158/0008-5472.CAN-22-2316.
7
Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma.Palladin 同种型 3 和 4 调节胰腺导管腺癌中癌症相关成纤维细胞的促肿瘤功能。
Sci Rep. 2021 Feb 15;11(1):3802. doi: 10.1038/s41598-021-82937-3.
8
Desmoplasia in Lymph Node Metastasis of Pancreatic Adenocarcinoma Reveals Activation of Cancer-Associated Fibroblasts Pattern and T-helper 2 Immune Cell Infiltration.胰腺腺癌淋巴结转移中的促纤维增生反应显示癌症相关成纤维细胞模式的激活和辅助性T细胞2免疫细胞浸润。
Pancreas. 2019 Mar;48(3):367-373. doi: 10.1097/MPA.0000000000001261.
9
α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.α11β1整合素在促结缔组织增生性肿瘤基质中的一部分癌症相关成纤维细胞中被诱导表达，并介导体外细胞迁移。
Cancers (Basel). 2019 Jun 1;11(6):765. doi: 10.3390/cancers11060765.
10
Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line.肿瘤相关成纤维细胞产生的白细胞介素-8 抑制 OCUCh-LM1 癌细胞系的增殖。
BMC Cancer. 2022 Jul 8;22(1):748. doi: 10.1186/s12885-022-09847-z.

引用本文的文献

1
Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers.用于胃肠道癌双模态近红外荧光和光声成像的聚糖靶向单克隆抗体的临床前评估
EJNMMI Res. 2025 Jun 6;15(1):67. doi: 10.1186/s13550-025-01258-y.
2
Radiation response assessment of organoids derived from patients with pancreatic cancer.胰腺癌患者来源类器官的辐射反应评估。
Clin Transl Radiat Oncol. 2024 Jul 27;48:100829. doi: 10.1016/j.ctro.2024.100829. eCollection 2024 Sep.
3
Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures.

本文引用的文献

1
Cancer statistics, 2022.癌症统计数据，2022 年。
CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
2
Cancer-Associated Fibroblast-Induced Resistance to Chemotherapy and Radiotherapy in Gastrointestinal Cancers.癌症相关成纤维细胞诱导的胃肠道癌症对化疗和放疗的抗性
Cancers (Basel). 2021 Mar 9;13(5):1172. doi: 10.3390/cancers13051172.
3
Diversity and Biology of Cancer-Associated Fibroblasts.癌症相关成纤维细胞的多样性与生物学特性。
用于患者来源的胰腺癌培养物中溶瘤病毒治疗疗效的生物标志物筛选。
EBioMedicine. 2024 Jul;105:105219. doi: 10.1016/j.ebiom.2024.105219. Epub 2024 Jun 27.
4
Evolving Tumor Characteristics and Smart Nanodrugs for Tumor Immunotherapy.肿瘤特征演进与智能纳米药物用于肿瘤免疫治疗。
Int J Nanomedicine. 2024 May 1;19:3919-3942. doi: 10.2147/IJN.S453265. eCollection 2024.
5
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool.用于治疗决策工具的胃肠道肿瘤患者衍生类器官的研究进展。
Biol Res. 2023 Dec 2;56(1):63. doi: 10.1186/s40659-023-00476-9.
6
Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus 'GoraVir' for the treatment of pancreatic ductal adenocarcinoma.用于治疗胰腺导管腺癌的大猩猩来源 HAdV-B AdV-lumc007 溶瘤腺病毒“GoraVir”的临床前评估。
Mol Oncol. 2024 May;18(5):1245-1258. doi: 10.1002/1878-0261.13561. Epub 2024 Jan 24.
7
Validation of a Novel EUS-FNB-Derived Organoid Co-Culture System for Drug Screening in Patients with Pancreatic Cancer.一种用于胰腺癌患者药物筛选的新型超声内镜引导下细针穿刺活检衍生类器官共培养系统的验证
Cancers (Basel). 2023 Jul 19;15(14):3677. doi: 10.3390/cancers15143677.
8
Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirus.表达连接黏附分子-A 的胃肠道癌相关成纤维细胞易于被溶瘤呼肠孤病毒感染。
Cancer Gene Ther. 2022 Dec;29(12):1918-1929. doi: 10.1038/s41417-022-00507-9. Epub 2022 Jul 22.
Physiol Rev. 2021 Jan 1;101(1):147-176. doi: 10.1152/physrev.00048.2019. Epub 2020 May 28.
4
Organoid models of gastrointestinal cancers in basic and translational research.胃肠癌的类器官模型在基础和转化研究中的应用。
Nat Rev Gastroenterol Hepatol. 2020 Apr;17(4):203-222. doi: 10.1038/s41575-019-0255-2. Epub 2020 Feb 25.
5
Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment.胰腺肿瘤微环境中的成纤维细胞异质性。
Cancer Discov. 2020 May;10(5):648-656. doi: 10.1158/2159-8290.CD-19-1353. Epub 2020 Feb 3.
6
Cancer modeling meets human organoid technology.癌症建模与人类类器官技术相遇。
Science. 2019 Jun 7;364(6444):952-955. doi: 10.1126/science.aaw6985.
7
Cancer-associated fibroblasts in gastrointestinal cancer.胃肠道癌症中的癌症相关成纤维细胞。
Nat Rev Gastroenterol Hepatol. 2019 May;16(5):282-295. doi: 10.1038/s41575-019-0115-0.
8
Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models.原发性人胰腺癌细胞类器官、匹配的基质和免疫细胞及 3D 肿瘤微环境模型的开发。
BMC Cancer. 2018 Mar 27;18(1):335. doi: 10.1186/s12885-018-4238-4.
9
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.人胰腺肿瘤类器官揭示了疾病进展过程中干细胞龛因子依赖性的丧失。
Cell Stem Cell. 2018 Mar 1;22(3):454-467.e6. doi: 10.1016/j.stem.2017.12.009. Epub 2018 Jan 11.
10
Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells.胰腺癌的器官型培养模型表明，基质细胞可调节肿瘤细胞中E-钙黏蛋白、β-连环蛋白和埃兹蛋白的表达。
Am J Pathol. 2009 Aug;175(2):636-48. doi: 10.2353/ajpath.2009.090131. Epub 2009 Jul 16.