State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2022 Jul 22;13:923475. doi: 10.3389/fendo.2022.923475. eCollection 2022.
Human-directed domestication of terrestrial animals traditionally requires thousands of years for breeding. The most prominent behavioral features of domesticated animals include reduced aggression and enhanced tameness relative to their wild forebears, and such behaviors improve the social tolerance of domestic animals toward both humans and crowds of their own species. These behavioral responses are primarily mediated by the hypothalamic-pituitary-adrenal (inter-renal in fish) (HPA/I) endocrine axis, which is involved in the rapid conversion of neuronal-derived perceptual information into hormonal signals. Over recent decades, growing evidence implicating the attenuation of the HPA/I axis during the domestication of animals have been identified through comprehensive genomic analyses of the paleogenomic datasets of wild progenitors and their domestic congeners. Compared with that of terrestrial animals, domestication of most farmed fish species remains at early stages. The present review focuses on the application of HPI signaling attenuation to accelerate the domestication and genetic breeding of farmed fish. We anticipate that deeper understanding of HPI signaling and its implementation in the domestication of farmed fish will benefit genetic breeding to meet the global demands of the aquaculture industry.
人类定向的陆生动物驯化传统上需要数千年的时间来进行繁殖。与野生祖先相比，驯化动物最显著的行为特征包括攻击性降低和温顺性增强，这些行为提高了家畜对人类和同类群体的社会容忍度。这些行为反应主要由下丘脑-垂体-肾上腺（鱼类中的间肾）（HPA/I）内分泌轴介导，该轴参与将神经元衍生的感知信息快速转化为激素信号。在过去的几十年中，通过对野生祖先及其家养同类的古基因组数据集进行全面的基因组分析，已经确定了动物驯化过程中 HPA/I 轴的衰减。与陆生动物相比，大多数养殖鱼类的驯化仍处于早期阶段。本综述重点介绍了 HPI 信号衰减在加速养殖鱼类驯化和遗传育种中的应用。我们预计，对 HPI 信号的深入了解及其在养殖鱼类驯化中的应用将有助于遗传育种，以满足全球水产养殖业的需求。
