Heitkemper M M, Shaver J F
Biol Neonate. 1987;51(5):277-85. doi: 10.1159/000242665.
The present study examined the effects of pentagastrin and adrenalectomy on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE), enzymes which synthesize and degrade acetylcholine in the rat gastrointestinal tract. Adrenalectomized and non-adrenalectomized rats, 14 and 21 days old, were treated with either pentagastrin (250 micrograms/kg i.p.) or saline for 7 days. Rats were sacrificed at 21 and 28 days of age. Adrenalectomy- and pentagastrin-treated 21-day-old rats had greater ChAT activities than those treated with pentagastrin alone, while AChE activities were higher in the pentagastrin-treated group. Adrenalectomy- and pentagastrin-treated 28-day-old rats had lower levels of activity as compared to pentagastrin-treated rats. The adrenal gland does appear to influence the response of cholinergic enzyme activities to pentagastrin.
本研究考察了五肽胃泌素和肾上腺切除术对大鼠胃肠道中合成及降解乙酰胆碱的酶——胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）的影响。对14日龄和21日龄的肾上腺切除大鼠及未切除大鼠，分别用五肽胃泌素（250微克/千克腹腔注射）或生理盐水处理7天。在21日龄和28日龄时处死大鼠。与仅用五肽胃泌素处理的大鼠相比，经肾上腺切除及五肽胃泌素处理的21日龄大鼠具有更高的ChAT活性，而五肽胃泌素处理组的AChE活性更高。与五肽胃泌素处理的大鼠相比，经肾上腺切除及五肽胃泌素处理的28日龄大鼠的活性水平较低。肾上腺似乎确实会影响胆碱能酶活性对五肽胃泌素的反应。
