7512 Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John's, Newfoundland and Labrador, Canada.
103974 Newlab Clinical Research, St. John's, Newfoundland and Labrador, Canada.
J Cutan Med Surg. 2022 Sep-Oct;26(5):494-501. doi: 10.1177/12034754221117736. Epub 2022 Aug 7.
Psoriasis is a chronic, immune-mediated inflammatory disease with an implied connection to psychiatric disorders.
This study aims to illustrate an association between psoriasis and psychiatric disorders using real world data gathered from the Newfoundland and Labrador population.
Data on 15,100 patients with psoriasis and 75,500 controls (1:5) was collected from the Newfoundland and Labrador Centre for Health Information's Electronic Health Records. The cases and controls were matched for age, sex, and geography. Indicators for psychiatric disorders include diagnosis of mental illnesses from physician's visits and hospitalization records (all coded for mental health using ICD-9 and ICD-10 codes).
9,991 (66.2%) cases were identified to have at least one visit with a diagnostic code for mental illness compared to 42,276 (56.0%), < .0001 in the control group. The percentage of people coded for anxiety was 36.50% compared to 28.95%, < .0001; depression was 37.04% compared to 30.19%, < .0001; and adjustment disorder was 6.89% versus 5.48%, < .0001, among those with and without psoriasis, respectively. The greatest risk for anxiety [OR 1.4 (1.20, 1.67)] and depression [OR 1.65 (1.36, 2.00)] among psoriasis patients was between the 0 to 20 age group. Women with psoriasis are more likely to have anxiety [OR 1.08 (1.03, 1.13)], depression [OR 1.04 (1.01, 1.09)] and adjustment disorder [OR 1.07 (0.98, 1.17)] compared to female controls.
Our result shows that patients with psoriasis have an increased prevalence of mental illness. Using real world data to carry out further investigations will better elucidate this association and provide an increased understanding of the association between psoriasis and mental disorders.
银屑病是一种慢性、免疫介导的炎症性疾病，与精神障碍有一定的关联。
本研究旨在使用来自纽芬兰和拉布拉多省人群的真实世界数据，说明银屑病与精神障碍之间的关联。
从纽芬兰和拉布拉多省卫生信息中心的电子健康记录中收集了 15100 名银屑病患者和 75500 名对照者（1:5）的数据。病例和对照者按年龄、性别和地理位置匹配。精神障碍的指标包括医生就诊和住院记录中的精神疾病诊断（所有精神健康诊断均使用 ICD-9 和 ICD-10 编码）。
9991 例（66.2%）患者至少有一次就诊记录被诊断为精神疾病，而对照组中这一比例为 42276 例（56.0%），<0.0001。编码为焦虑症的人数比例为 36.50%，而对照组为 28.95%，<0.0001；抑郁症的比例为 37.04%，而对照组为 30.19%，<0.0001；调整障碍的比例为 6.89%，而对照组为 5.48%，<0.0001。在有和没有银屑病的患者中，焦虑症的风险最高[比值比（OR）1.4（1.20，1.67）]和抑郁症[OR 1.65（1.36，2.00）]分别发生在 0 至 20 岁年龄组。与女性对照组相比，患有银屑病的女性更容易患焦虑症[OR 1.08（1.03，1.13）]、抑郁症[OR 1.04（1.01，1.09）]和调整障碍[OR 1.07（0.98，1.17）]。
我们的结果表明，银屑病患者的精神疾病患病率较高。使用真实世界数据进行进一步研究将更好地阐明这种关联，并提高对银屑病与精神障碍之间关联的认识。
