Gulliver Wayne P, Randell Shane, Gulliver Susanne, Macdonald Don, Gregory Valerie, Nagle Sean, Chambenoit Olivier
1 Newlab Clinical Research, St. John's, NL, Canada.
2 Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
J Cutan Med Surg. 2019 Jan/Feb;23(1):29-34. doi: 10.1177/1203475418791114. Epub 2018 Jul 24.
Psoriasis is an inflammatory skin condition affecting 2% to 3% of the population and is associated with several comorbidities, including cardiovascular disease, depression, inflammatory bowel disease, metabolic syndrome, mood disorder, psoriatic arthritis, and weight gain. Psoriasis is treated with a number of topical and systemic therapies, including biologic drugs that directly target proinflammatory cytokines. This cross-sectional retrospective study investigated comorbid conditions reported in the Newfoundland and Labrador psoriasis population, outcomes associated with therapeutic treatment, and use of health care resources. Of the psoriasis comorbidities investigated, psoriatic arthritis was significantly associated with the use of biologic therapy while a failure to respond to biologics was associated with a higher incidence of cardiovascular disease. Patients responsive to biologic treatment had fewer hospital stays than patients treated with other therapies. Our results suggest that biologic therapies have a cardioprotective effect and reduce the number of hospital visits in patients whose symptoms are responsive to treatment.
银屑病是一种炎症性皮肤病，影响着2%至3%的人口，并与多种合并症相关，包括心血管疾病、抑郁症、炎症性肠病、代谢综合征、情绪障碍、银屑病关节炎和体重增加。银屑病可通过多种局部和全身疗法进行治疗，包括直接靶向促炎细胞因子的生物药物。这项横断面回顾性研究调查了纽芬兰和拉布拉多银屑病患者群体中报告的合并症、治疗相关结果以及医疗资源的使用情况。在所调查的银屑病合并症中，银屑病关节炎与生物治疗的使用显著相关，而对生物制剂无反应则与心血管疾病的较高发病率相关。对生物治疗有反应的患者住院次数少于接受其他疗法治疗的患者。我们的结果表明，生物疗法具有心脏保护作用，并减少了症状对治疗有反应的患者的就诊次数。
