涉及乙胺丁醇耐药的基因和调控网络。

The Gene and Regulatory Network Involved in Ethambutol Resistance in .

机构信息

Institute of Modern Biopharmaceuticals State Key Laboratory, Breeding Base Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, China.

Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assuit, Egypt.

出版信息

Microb Drug Resist. 2023 May;29(5):175-189. doi: 10.1089/mdr.2021.0239. Epub 2022 Aug 8.

DOI:10.1089/mdr.2021.0239

PMID:35939307

Abstract

Ethambutol (EMB) is used in combination with isoniazid and rifampicin for the treatment of tuberculosis caused by . However, the incidence of EMB resistance is alarming. The EMB targets the cell wall arabinan biosynthesis. It is important to comprehensively understand the molecular basis of EMB to slow down the drug resistance rate of EMB. This study summarized the genes implicated in EMB resistance, regulatory network and the pharmacoproteomic effect of EMB in . Many of the genes related to EMB are implicated in membrane components, drug efflux, lipid metabolism, ribosome, and detoxification. The differential response model may help to design a novel anti-tuberculosis antibiotic.

摘要

乙胺丁醇（EMB）与异烟肼和利福平联合用于治疗引起的肺结核。然而，EMB 耐药性的发生率令人震惊。EMB 的作用靶点是细胞壁阿拉伯聚糖生物合成。全面了解 EMB 的分子基础对于减缓 EMB 的耐药率非常重要。本研究总结了与 EMB 耐药性相关的基因、调控网络以及 EMB 在中的药物保护组学效应。许多与 EMB 相关的基因涉及膜成分、药物外排、脂质代谢、核糖体和解毒。差异反应模型可能有助于设计新型抗结核抗生素。