内分泌干扰化学物质对脑单胺和认知行为的性别特异性影响。
Sex-specific Effects of Endocrine-disrupting Chemicals on Brain Monoamines and Cognitive Behavior.
机构信息
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas, 78712, USA.
Institute for Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA.
出版信息
Endocrinology. 2022 Oct 1;163(10). doi: 10.1210/endocr/bqac128.
The period of brain sexual differentiation is characterized by the development of hormone-sensitive neural circuits that govern the subsequent presentation of sexually dimorphic behavior in adulthood. Perturbations of hormones by endocrine-disrupting chemicals (EDCs) during this developmental period interfere with an organism's endocrine function and can disrupt the normative organization of male- or female-typical neural circuitry. This is well characterized for reproductive and social behaviors and their underlying circuitry in the hypothalamus and other limbic regions of the brain; however, cognitive behaviors are also sexually dimorphic, with their underlying neural circuitry potentially vulnerable to EDC exposure during critical periods of brain development. This review provides recent evidence for sex-specific changes to the brain's monoaminergic systems (dopamine, serotonin, norepinephrine) after developmental EDC exposure and relates these outcomes to sex differences in cognition such as affective, attentional, and learning/memory behaviors.
大脑性别分化的时期以激素敏感的神经回路的发展为特征，这些神经回路支配成年后表现出的性别二态行为。在这一发育时期，内分泌干扰化学物质（EDCs）对激素的干扰会干扰生物体的内分泌功能，并破坏男性或女性典型神经回路的正常组织。这在生殖和社会行为及其在大脑下丘脑和其他边缘区域的基础电路中得到了很好的描述；然而，认知行为也是性别二态的，其潜在的神经回路可能容易受到大脑发育关键时期 EDC 暴露的影响。这篇综述提供了最近的证据，证明发育性 EDC 暴露后大脑单胺能系统（多巴胺、血清素、去甲肾上腺素）的性别特异性变化，并将这些结果与认知方面的性别差异联系起来，如情感、注意力和学习/记忆行为。
Zotero 插件