[酶在大鼠辐射、骨折及复合辐射损伤期间对骨髓细胞抗氧化保护的作用]

[The function of enzymes for the antioxidative protection of the bone marrow cells in rats during irradiation, bone fracture and combined radiation injury].

作者信息

Bogdanova I A, Ovchinnikov K G, Torbenko V P, Gerasimov A M

出版信息

Biull Eksp Biol Med. 1987 Jun;103(6):659-62.

Abstract

The activity of superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione: dehydroascorbate oxidoreductase is lower in the bone marrow than in the liver. The changes in the cellular antioxidative enzymatic system during leg bones fracture and X-ray irradiation are more pronounced in the rat bone marrow, as compared to the liver. The data obtained are in keeping with selective bone-marrow radiosensitivity and with the effect of exogenous superoxide dismutase and glutathione as radioprotectors.

摘要

超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶以及谷胱甘肽：脱氢抗坏血酸氧化还原酶的活性在骨髓中低于肝脏。与肝脏相比，大鼠骨髓中腿部骨折和X射线照射期间细胞抗氧化酶系统的变化更为明显。所获得的数据与骨髓的选择性放射敏感性以及外源性超氧化物歧化酶和谷胱甘肽作为辐射防护剂的作用相符。

相似文献

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