[心肌缺血期间抗氧化酶的活性]
[Activity of antioxidative enzymes of the myocardium during ischemia].
作者信息
Gutkin D V, Petrovich Iu A
出版信息
Biull Eksp Biol Med. 1982 Jan;93(1):33-5.
Activation of lipid peroxidation during myocardial ischemia may be determined by the reduction of the enzymatic antioxidant cell protection. Such a conclusion has been drawn on the basis of an analysis of variation in the activity of superoxide dismutase, glutathion peroxidase and catalase in experimental myocardial ischemia in rats, induced by ligation of the left descending artery of the heart. In the early period of ischemia (1-3 h) the activity of superoxide dismutase and glutation peroxidase markedly decreases. In the periischemic zone, the fall in the enzymatic activity is not so pronounced. The activity of the enzymes does not reach the basic level 5 days after the operation.
心肌缺血期间脂质过氧化的激活可能由酶促抗氧化细胞保护作用的降低所决定。这一结论是基于对大鼠实验性心肌缺血（通过结扎心脏左冠状动脉前降支诱导）中超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性变化的分析得出的。在缺血早期（1 - 3小时），超氧化物歧化酶和谷胱甘肽过氧化物酶的活性显著降低。在缺血周边区域，酶活性的下降没有那么明显。术后5天，酶的活性仍未恢复到基础水平。
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