Duckles S P
Blood Vessels. 1987;24(3):113-6. doi: 10.1159/000158681.
The adrenergic neuroeffector mechanism of blood vessels in Fischer 344 rats was studied from young adulthood to senescence. Norepinephrine (NE) content is maintained through senescence in all veins studied as well as in the superior mesenteric artery. In contrast, NE content declined at 27 months of age in all other arteries studied. Nevertheless, vascular reactivity in vitro to adrenergic nerve stimulation and to NE was well maintained. As to beta-adrenergic responsiveness, this showed a marked decline in arteries from 1 to 6 months of age, but was unchanged in the jugular vein from 3 to 27 months. Overall, then, adrenergic responsiveness of vascular smooth muscle is well maintained in aged rats. However, this study focuses on a discrete aspect of blood pressure control in a species where atherosclerosis is not prominent. Alterations at other sites could be responsible for changes in the overall function of adrenergic cardiovascular control.
对Fischer 344大鼠从成年早期到衰老阶段的血管肾上腺素能神经效应机制进行了研究。在所有研究的静脉以及肠系膜上动脉中，去甲肾上腺素（NE）含量在衰老过程中保持稳定。相比之下，在所有其他研究的动脉中，NE含量在27月龄时下降。然而，体外血管对肾上腺素能神经刺激和NE的反应性保持良好。至于β-肾上腺素能反应性，在1至6月龄的动脉中显著下降，但在3至27月龄的颈静脉中没有变化。总体而言，老年大鼠血管平滑肌的肾上腺素能反应性保持良好。然而，本研究关注的是动脉粥样硬化不突出的一个物种中血压控制的一个离散方面。其他部位的改变可能导致肾上腺素能心血管控制整体功能的变化。
