Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Gen Comp Endocrinol. 2022 Nov 1;328:114101. doi: 10.1016/j.ygcen.2022.114101. Epub 2022 Aug 5.
Bradykinin is a well-studied bioactive peptide associated with several physiological functions, including vasodilation and inflammation, in mammals. However, its avian homolog, ornithokinin, has received less research attention in birds. Therefore this study aimed to investigate the effect of intraperitoneal (IP) and intracerebroventricular (ICV) injections of ornithokinin on feeding behavior, cloacal temperature, voluntary activity, crop emptying rate, and blood constituents in chicks (Gallus gallus). We also investigated the effect of lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria, on ornithokinin-associated gene expression was also investigated to determine whether activation of the ornithokinin system is induced by bacterial infection. Both IP and ICV injections of ornithokinin significantly decreased feed intake, cloacal temperature, voluntary activity, and crop emptying rate in chicks, but they did not affect the plasma concentration of corticosterone. Additionally, LPS significantly increased the expression of ornithokinin B2 receptor mRNA in several organs. Hence, ornithokinin is associated with a range of physiological responses in chicks and may be related to their response to bacterial infection.
缓激肽是一种研究充分的生物活性肽，与哺乳动物的几种生理功能有关，包括血管舒张和炎症。然而，鸟类的同源物——鸟胰高血糖素，在鸟类中受到的研究关注较少。因此，本研究旨在探讨腹腔内（IP）和脑室内（ICV）注射鸟胰高血糖素对小鸡（Gallus gallus）摄食行为、泄殖腔温度、自发活动、嗉囊排空率和血液成分的影响。我们还研究了脂多糖（LPS），革兰氏阴性菌细胞壁的组成部分，对鸟胰高血糖素相关基因表达的影响，以确定鸟胰高血糖素系统的激活是否是由细菌感染引起的。腹腔内和脑室内注射鸟胰高血糖素均显著降低了小鸡的采食量、泄殖腔温度、自发活动和嗉囊排空率，但对皮质酮的血浆浓度没有影响。此外，LPS 显著增加了几种器官中鸟胰高血糖素 B2 受体 mRNA 的表达。因此，鸟胰高血糖素与小鸡的一系列生理反应有关，可能与它们对细菌感染的反应有关。
